TCM@MPXV: A Resource for Treating Monkeypox Patients in Traditional Chinese Medicine

Introduction: Traditional Chinese Medicine (TCM) has been extensively employed in the treatment of Monkeypox Virus (MPXV) infections, and it has historically played a significant role in combating diseases like contagious pox-like viral diseases in China. Method: Various traditional Chinese medicine (TCM) therapies have been recommended for patients with monkeypox virus (MPXV). However, as far as we know, there is no comprehensive database dedicated to preserving and coordinating TCM remedies for combating MPXV. To address this gap, we introduce TCM@MPXV, a carefully curated repository of research materials focusing on formulations with anti-MPXV properties. Importantly, TCM@MPXV extends its scope beyond herbal remedies, encompassing mineral-based medicines as well. Result: The current iteration of TCM@MPXV boasts an impressive array of features, including (1) Documenting over 42 types of TCM herbs, with more than 27 unique herbs; (2) Recording over 285 bioactivity compounds within these herbs; (3) Launching a user-friendly web server for the docking, analysis, and visualization of 2D or 3D molecular structures; and (4) Providing 3D structures of druggable proteins of MPXV. Conclusion: To summarize, TCM@MPXV presents a user-friendly and effective platform for recording, querying, and viewing anti-MPXV TCM resources and will contribute to the development and explanation of novel anti-MPXV mechanisms of action to aid in the ongoing battle against monkeypox. TCM@MPXV is accessible for academic use at http://101.34.238.132:5000/.