S. Andrew Josephson MD, Michael S. Tennekoon PhD, S. Thomas Carmichael MD, PhD, Sydney S. Cash MD, PhD, John A. Detre MD, Argye E. Hillis MD, MA, Page B. Pennell MD, Scott L. Pomeroy MD, PhD, George B. Richerson MD, PhD, Lauren H. Sansing MD, MS, Stephen J. Korn PhD
{"title":"成功培养神经病学临床科学家的方法：NINDS R25 的经验。","authors":"S. Andrew Josephson MD, Michael S. Tennekoon PhD, S. Thomas Carmichael MD, PhD, Sydney S. Cash MD, PhD, John A. Detre MD, Argye E. Hillis MD, MA, Page B. Pennell MD, Scott L. Pomeroy MD, PhD, George B. Richerson MD, PhD, Lauren H. Sansing MD, MS, Stephen J. Korn PhD","doi":"10.1002/ana.27050","DOIUrl":null,"url":null,"abstract":"<div>\n \n <section>\n \n <h3> Objective</h3>\n \n <p>Training clinician–scientists is a primary objective of many academic neurology departments, as these individuals are uniquely positioned to perform insightful clinical or laboratory-based research informed both by clinical knowledge and their own experiences caring for patients. Despite its importance, training clinician–scientists has perhaps never been so challenging. The National Institute of Neurologic Disorders and Stroke (NINDS) R25 program was designed in an attempt to support these individuals, decrease the time needed to obtain National Institutes of Health K awards, and to help educate a cohort of trainees preparing for a career in academic neurology. We endeavored to describe the structure and features of the program while examining its outcomes.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>R25 outcome data from 2009 to 2024 were reviewed. Statistical comparisons were made using 2-sided Mann–Whitney <i>U</i> testing.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>A total of 67% of adult neurologists who received an R25 had a successful application for a National Institutes of Health K award compared with 45% of adult neurologists who had not received R25 support (<i>p</i> < 0.0001). Among child neurologists, 73% who applied went on to receive K funding after R25 support, compared with 45% who had not been part of the R25 program (<i>p</i> < 0.001). The average time between completion of residency and obtaining a K award for R25 participants was decreased by 26 months among those with an MD/PhD degree, and 32 months for those with an MD degree compared with non-R25 individuals.</p>\n </section>\n \n <section>\n \n <h3> Interpretation</h3>\n \n <p>The R25 program has been successful in achieving its training goals, but stands as only one component of support for aspiring clinician–scientists. Investments and commitments made by academic neurology departments are key to supporting this success. 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Korn PhD\",\"doi\":\"10.1002/ana.27050\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>Training clinician–scientists is a primary objective of many academic neurology departments, as these individuals are uniquely positioned to perform insightful clinical or laboratory-based research informed both by clinical knowledge and their own experiences caring for patients. Despite its importance, training clinician–scientists has perhaps never been so challenging. The National Institute of Neurologic Disorders and Stroke (NINDS) R25 program was designed in an attempt to support these individuals, decrease the time needed to obtain National Institutes of Health K awards, and to help educate a cohort of trainees preparing for a career in academic neurology. 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引用次数: 0
摘要
目的：培训临床科学家是许多神经病学学术部门的首要目标，因为这些人具有得天独厚的优势，能够根据临床知识和自身护理病人的经验，开展有见地的临床或实验室研究。尽管非常重要，但培养临床科学家或许从未如此具有挑战性。美国国立神经疾病与中风研究所（NINDS）R25 计划的设计初衷就是为这些人提供支持，缩短他们获得美国国立卫生研究院 K 奖项所需的时间，并帮助教育一批准备投身神经病学学术研究的受训人员。我们努力描述该计划的结构和特点，同时研究其成果：我们回顾了 2009 年至 2024 年的 R25 成果数据。采用双侧曼-惠特尼 U 检验法进行统计比较：结果：在获得 R25 支持的成年神经学家中，共有 67% 的人成功申请到了美国国立卫生研究院的 K 奖，而在未获得 R25 支持的成年神经学家中，只有 45% 的人成功申请到了 K 奖（P 解释：R25 计划在神经科学领域取得了成功：R25 计划成功地实现了其培训目标，但它只是为有抱负的临床科学家提供支持的一个组成部分。神经病学学术部门的投资和承诺是支持这一成功的关键。ann neurol 2024.
An Approach to Successful Development of Clinician–Scientists in Neurology: The NINDS R25 Experience
Objective
Training clinician–scientists is a primary objective of many academic neurology departments, as these individuals are uniquely positioned to perform insightful clinical or laboratory-based research informed both by clinical knowledge and their own experiences caring for patients. Despite its importance, training clinician–scientists has perhaps never been so challenging. The National Institute of Neurologic Disorders and Stroke (NINDS) R25 program was designed in an attempt to support these individuals, decrease the time needed to obtain National Institutes of Health K awards, and to help educate a cohort of trainees preparing for a career in academic neurology. We endeavored to describe the structure and features of the program while examining its outcomes.
Methods
R25 outcome data from 2009 to 2024 were reviewed. Statistical comparisons were made using 2-sided Mann–Whitney U testing.
Results
A total of 67% of adult neurologists who received an R25 had a successful application for a National Institutes of Health K award compared with 45% of adult neurologists who had not received R25 support (p < 0.0001). Among child neurologists, 73% who applied went on to receive K funding after R25 support, compared with 45% who had not been part of the R25 program (p < 0.001). The average time between completion of residency and obtaining a K award for R25 participants was decreased by 26 months among those with an MD/PhD degree, and 32 months for those with an MD degree compared with non-R25 individuals.
Interpretation
The R25 program has been successful in achieving its training goals, but stands as only one component of support for aspiring clinician–scientists. Investments and commitments made by academic neurology departments are key to supporting this success. ANN NEUROL 2024;96:625–632
期刊介绍：
Annals of Neurology publishes original articles with potential for high impact in understanding the pathogenesis, clinical and laboratory features, diagnosis, treatment, outcomes and science underlying diseases of the human nervous system. Articles should ideally be of broad interest to the academic neurological community rather than solely to subspecialists in a particular field. Studies involving experimental model system, including those in cell and organ cultures and animals, of direct translational relevance to the understanding of neurological disease are also encouraged.
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