全面概述液体活检在小儿实体瘤中的应用。

IF 6.8 1区 医学 Q1 ONCOLOGY NPJ Precision Oncology Pub Date : 2024-08-03 DOI:10.1038/s41698-024-00657-z
Ferdinand W. Janssen, Nathalie S. M. Lak, Claudia Y. Janda, Lennart A. Kester, Michael T. Meister, Johannes H. M. Merks, Marry M. van den Heuvel-Eibrink, Max M. van Noesel, Jozsef Zsiros, Godelieve A. M. Tytgat, Leendert H. J. Looijenga
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引用次数: 0

摘要

液体活检正在成为儿科癌症生物标记物的另一种来源,在从诊断到长期随访的患者护理的各个阶段都有潜在的应用价值。虽然这一领域的发展已有报道,但主要集中在特定的项目上,如特定的液体活检基质、分析物和/或单一肿瘤类型。据我们所知,目前还缺乏一份全面的综述。在此,我们回顾了针对最常见的非中枢神经系统小儿实体瘤的液体活检研究现状。这些肿瘤包括神经母细胞瘤、肾肿瘤、生殖细胞瘤、骨肉瘤、尤文肉瘤、横纹肌肉瘤和其他软组织肉瘤以及肝肿瘤。在这个选题中,我们讨论了涉及基于液态活检的生物标记物的最重要或最新研究、预期的临床应用以及当前成功所面临的挑战。此外,我们还根据 1989 年至 2023 年间的全面文献检索,概述了每种肿瘤类型的基于液态活检的生物标记物发表情况。我们为每项研究列出了相关的基于液体活检的生物标记物、基质(如外周血、骨髓或脑脊液)、分析物(如循环无细胞DNA和肿瘤DNA、microRNAs和循环肿瘤细胞)、方法(如数字液滴PCR和新一代测序)、涉及的儿科患者群以及建议的应用。因此,我们发现了 344 篇独特的出版物。综上所述,虽然儿科肿瘤的液体活检领域仍落后于成人肿瘤,但在过去十年中,潜在的相关出版物有所增加。重要的是,通过在儿科临床试验中验证基于液体活检的生物标记物,临床实施的步骤正在迅速推进。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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A comprehensive overview of liquid biopsy applications in pediatric solid tumors
Liquid biopsies are emerging as an alternative source for pediatric cancer biomarkers with potential applications during all stages of patient care, from diagnosis to long-term follow-up. While developments within this field are reported, these mainly focus on dedicated items such as a specific liquid biopsy matrix, analyte, and/or single tumor type. To the best of our knowledge, a comprehensive overview is lacking. Here, we review the current state of liquid biopsy research for the most common non-central nervous system pediatric solid tumors. These include neuroblastoma, renal tumors, germ cell tumors, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma and other soft tissue sarcomas, and liver tumors. Within this selection, we discuss the most important or recent studies involving liquid biopsy-based biomarkers, anticipated clinical applications, and the current challenges for success. Furthermore, we provide an overview of liquid biopsy-based biomarker publication output for each tumor type based on a comprehensive literature search between 1989 and 2023. Per study identified, we list the relevant liquid biopsy-based biomarkers, matrices (e.g., peripheral blood, bone marrow, or cerebrospinal fluid), analytes (e.g., circulating cell-free and tumor DNA, microRNAs, and circulating tumor cells), methods (e.g., digital droplet PCR and next-generation sequencing), the involved pediatric patient cohort, and proposed applications. As such, we identified 344 unique publications. Taken together, while the liquid biopsy field in pediatric oncology is still behind adult oncology, potentially relevant publications have increased over the last decade. Importantly, steps towards clinical implementation are rapidly gaining ground, notably through validation of liquid biopsy-based biomarkers in pediatric clinical trials.
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来源期刊
CiteScore
9.90
自引率
1.30%
发文量
87
审稿时长
18 weeks
期刊介绍: Online-only and open access, npj Precision Oncology is an international, peer-reviewed journal dedicated to showcasing cutting-edge scientific research in all facets of precision oncology, spanning from fundamental science to translational applications and clinical medicine.
期刊最新文献
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