{"title":"法洛氏四联症患者左心室结构完整性：纵向弛豫时间绘图法。","authors":"Giorgos Broumpoulis, Efstratios Karavasilis, Niki Lama, Ioannis Papadopoulos, Panagiotis Zachos, Sotiria Apostolopoulou, Nikolaos Kelekis","doi":"10.1117/1.JMI.11.4.044004","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Tetralogy of Fallot (TOF) is a congenital heart disease, and patients undergo surgical repair early in their lives. The evaluation of TOF patients is continuous through their adulthood. The use of cardiac magnetic resonance imaging (CMR) is vital for the evaluation of TOF patients. We aim to correlate advanced MRI sequences [parametric longitudinal relaxation time (T1), extracellular volume (ECV) mapping] with cardiac functionality to provide biomarkers for the evaluation of these patients.</p><p><strong>Methods: </strong>A complete CMR examination with the same imaging protocol was conducted in a total of 11 TOF patients and a control group of 25 healthy individuals. A Modified Look-Locker Inversion recovery (MOLLI) sequence was included to acquire the global T1 myocardial relaxation times of the left ventricular (LV) pre and post-contrast administration. Appropriate software (Circle cmr42) was used for the CMR analysis and the calculation of native, post-contrast T1, and ECV maps. A regression analysis was conducted for the correlation between global LV T1 values and right ventricular (RV) functional indices.</p><p><strong>Results: </strong>Statistically significant results were obtained for RV cardiac index [RV_CI= -32.765 + 0.029 × T1 native; <math><mrow><mi>p</mi> <mo>=</mo> <mn>0.003</mn></mrow> </math> ], RV end diastolic volume [RV_EDV/BSA = -1023.872 + 0.902 × T1 native; <math><mrow><mi>p</mi> <mo>=</mo> <mn>0.001</mn></mrow> </math> ], and RV end systolic volume [RV_ESV/BSA = -536.704 + 0.472 × T1 native; <math><mrow><mi>p</mi> <mo>=</mo> <mn>0.011</mn></mrow> </math> ].</p><p><strong>Conclusions: </strong>We further support the diagnostic importance of T1 mapping as a structural imaging tool in CMR. In addition to the well-known affected RV function in TOF patients, the LV structure is also impaired as there is a strong correlation between LV T1 mapping and RV function, evoking that the heart operates as an entity.</p>","PeriodicalId":47707,"journal":{"name":"Journal of Medical Imaging","volume":"11 4","pages":"044004"},"PeriodicalIF":1.9000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11293558/pdf/","citationCount":"0","resultStr":"{\"title\":\"Left ventricular structural integrity on tetralogy of Fallot patients: approach using longitudinal relaxation time mapping.\",\"authors\":\"Giorgos Broumpoulis, Efstratios Karavasilis, Niki Lama, Ioannis Papadopoulos, Panagiotis Zachos, Sotiria Apostolopoulou, Nikolaos Kelekis\",\"doi\":\"10.1117/1.JMI.11.4.044004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Tetralogy of Fallot (TOF) is a congenital heart disease, and patients undergo surgical repair early in their lives. The evaluation of TOF patients is continuous through their adulthood. The use of cardiac magnetic resonance imaging (CMR) is vital for the evaluation of TOF patients. We aim to correlate advanced MRI sequences [parametric longitudinal relaxation time (T1), extracellular volume (ECV) mapping] with cardiac functionality to provide biomarkers for the evaluation of these patients.</p><p><strong>Methods: </strong>A complete CMR examination with the same imaging protocol was conducted in a total of 11 TOF patients and a control group of 25 healthy individuals. A Modified Look-Locker Inversion recovery (MOLLI) sequence was included to acquire the global T1 myocardial relaxation times of the left ventricular (LV) pre and post-contrast administration. Appropriate software (Circle cmr42) was used for the CMR analysis and the calculation of native, post-contrast T1, and ECV maps. A regression analysis was conducted for the correlation between global LV T1 values and right ventricular (RV) functional indices.</p><p><strong>Results: </strong>Statistically significant results were obtained for RV cardiac index [RV_CI= -32.765 + 0.029 × T1 native; <math><mrow><mi>p</mi> <mo>=</mo> <mn>0.003</mn></mrow> </math> ], RV end diastolic volume [RV_EDV/BSA = -1023.872 + 0.902 × T1 native; <math><mrow><mi>p</mi> <mo>=</mo> <mn>0.001</mn></mrow> </math> ], and RV end systolic volume [RV_ESV/BSA = -536.704 + 0.472 × T1 native; <math><mrow><mi>p</mi> <mo>=</mo> <mn>0.011</mn></mrow> </math> ].</p><p><strong>Conclusions: </strong>We further support the diagnostic importance of T1 mapping as a structural imaging tool in CMR. In addition to the well-known affected RV function in TOF patients, the LV structure is also impaired as there is a strong correlation between LV T1 mapping and RV function, evoking that the heart operates as an entity.</p>\",\"PeriodicalId\":47707,\"journal\":{\"name\":\"Journal of Medical Imaging\",\"volume\":\"11 4\",\"pages\":\"044004\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11293558/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Medical Imaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1117/1.JMI.11.4.044004\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/8/1 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medical Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1117/1.JMI.11.4.044004","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/1 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Left ventricular structural integrity on tetralogy of Fallot patients: approach using longitudinal relaxation time mapping.
Purpose: Tetralogy of Fallot (TOF) is a congenital heart disease, and patients undergo surgical repair early in their lives. The evaluation of TOF patients is continuous through their adulthood. The use of cardiac magnetic resonance imaging (CMR) is vital for the evaluation of TOF patients. We aim to correlate advanced MRI sequences [parametric longitudinal relaxation time (T1), extracellular volume (ECV) mapping] with cardiac functionality to provide biomarkers for the evaluation of these patients.
Methods: A complete CMR examination with the same imaging protocol was conducted in a total of 11 TOF patients and a control group of 25 healthy individuals. A Modified Look-Locker Inversion recovery (MOLLI) sequence was included to acquire the global T1 myocardial relaxation times of the left ventricular (LV) pre and post-contrast administration. Appropriate software (Circle cmr42) was used for the CMR analysis and the calculation of native, post-contrast T1, and ECV maps. A regression analysis was conducted for the correlation between global LV T1 values and right ventricular (RV) functional indices.
Results: Statistically significant results were obtained for RV cardiac index [RV_CI= -32.765 + 0.029 × T1 native; ], RV end diastolic volume [RV_EDV/BSA = -1023.872 + 0.902 × T1 native; ], and RV end systolic volume [RV_ESV/BSA = -536.704 + 0.472 × T1 native; ].
Conclusions: We further support the diagnostic importance of T1 mapping as a structural imaging tool in CMR. In addition to the well-known affected RV function in TOF patients, the LV structure is also impaired as there is a strong correlation between LV T1 mapping and RV function, evoking that the heart operates as an entity.
期刊介绍：
JMI covers fundamental and translational research, as well as applications, focused on medical imaging, which continue to yield physical and biomedical advancements in the early detection, diagnostics, and therapy of disease as well as in the understanding of normal. The scope of JMI includes: Imaging physics, Tomographic reconstruction algorithms (such as those in CT and MRI), Image processing and deep learning, Computer-aided diagnosis and quantitative image analysis, Visualization and modeling, Picture archiving and communications systems (PACS), Image perception and observer performance, Technology assessment, Ultrasonic imaging, Image-guided procedures, Digital pathology, Biomedical applications of biomedical imaging. JMI allows for the peer-reviewed communication and archiving of scientific developments, translational and clinical applications, reviews, and recommendations for the field.
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