[防治血吸虫病的肥皂:值得考虑的实地干预措施?]

Medecine tropicale et sante internationale Pub Date : 2024-04-08 eCollection Date: 2024-06-30 DOI:10.48327/mtsi.v4i2.2024.508
Jean-Loup Rey
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引用次数: 0

摘要

1985-87 年,使用中和血吸虫中间阶段的产品进行了一项防治血吸虫病的实验。实验室研究表明,用于儿童洗发水的月桂基甜菜碱类两性物质能迅速固定弧菌和蛔虫。在尼日尔对含有有机物的水进行的实地研究也得出了类似的结果。这种表面活性剂可以添加到普通肥皂中,剂量为 5%,而不会改变肥皂的特性。甜菜碱肥皂在尼日尔的普通商业渠道上市销售,随后又在科特迪瓦的血吸虫高发村庄上市销售。甜菜碱在没有外来干预的情况下扩散到人们的洗涤用水中。这些居民对肥皂的接受程度很高。然而,一年后,与对照村相比,试验村在尿血吸虫病流行率和卵尿方面的动态结果并不明确。抗血吸虫治疗似乎有必要在程序开始时进行。需要对人群使用肥皂的情况进行测量。总之,除了健康教育和系统的治疗行动外,这一前景看好的实验室行动值得在实地再次评估。
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[A soap to fight schistosomiasis: a field intervention worth considering?]

An experiment was carried out in 1985-87 against schistosomiasis using products neutralizing the intermediate stages of schistosomes. In the laboratory, it had been shown that lauryl betaines, amphoteric substances, used for children's shampoos, quickly immobilized miracidiums and cercariae. Studies in Niger in field conditions with water laden with organic matter gave similar results. This surfactant can be incorporated into ordinary soaps at a dose of 5% without changing their characteristics. Betaine soaps were put on sale in ordinary commercial channels in Niger then in Côte d'Ivoire, in hyperendemic villages for Schistosoma haematobium. Betaines diffused without external intervention into the water used by populations for washing. The soaps were well accepted by these populations. However, after one year, the results in tested villages compared to control ones were unclear on the dynamics of urinary schistosomiasis in terms of prevalence and oviuria. Anti-schistosome treatment seems necessary at the start of the procedure. The use of soap by populations needed to be measured. In conclusion, this promising laboratory action deserves to be evaluated again in the field, in addition to health education and systematic treatment actions.

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