探索类风湿性关节炎相关间质性肺病--来自沙特两家三级医疗中心的回顾性研究。

IF 2.1 Q3 RHEUMATOLOGY BMC Rheumatology Pub Date : 2024-08-05 DOI:10.1186/s41927-024-00403-9
Ayah M Boudal, Rafif G Alsaigh, Nuha N Alrajhi, Majdy M Idrees, Mohammed A Omair, Hanan Mohammed Al Rayes, Mufaddal Adil Alaithan, Esam H Alhamad, Nayef Hadi Alqahtani, Kawther Ghassan Bohuliga, Nawaf Y Alenezi, Fawaz A Alharbi
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引用次数: 0

摘要

背景:间质性肺病(ILD)是类风湿性关节炎(RA)日益公认的并发症,与严重的发病率和死亡率相关。与 RA 相关的 ILD 的风险因素有很多。本研究旨在探讨沙特 RA-ILD 患者的特征和风险因素:这是一项针对 RA-ILD 患者的多中心、回顾性、观察性研究。从电子病历中获取 RA-ILD 患者的临床和放射学数据,包括人口统计学、临床特征、实验室检查、肺功能检查、ECHO 和 HRCT 图像:结果:在 732 名患者中,57 人患有 RA-ILD。确诊 ILD 时的平均年龄为 61.9(± 12.2)岁。确诊为 RA-ILD 的女性患者明显较少(P = 0.008)。曾经吸烟的患者患 RA-ILD 的比例明显更高(P 0.05)。RA-ILD 最常见的症状是咳嗽(55.6%)和呼吸困难(30.2%),最常见的 ILD 模式是非特异性间质性肺炎(55.6%),其次是普通间质性肺炎(38.9%)。此外,还观察到牵引性支气管扩张(75.5%)和玻璃样不透明(73.6%)。基线平均 FVC 和 DLCO 分别为 64.6% 和 53.3%:结论:在这批患者中,沙特 RA-ILD 患者以 NSIP 模式为主,这与全球的情况相反。这些发现可能是因为我国患者吸烟率较低。今后需要开展前瞻性全国研究,以证实当前的研究结果,并更好地评估 RA-ILD 的流行病学和风险因素。
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Exploring rheumatoid arthritis associated interstitial lung disease a retrospective study from two Saudi tertiary care centers.

Background: Interstitial lung disease (ILD) is an increasingly recognized complication of rheumatoid arthritis (RA) and is associated with significant morbidity and mortality. Many risk factors for RA-related ILD were reported. The current study aims to explore the features and risk factors of Saudi patients with RA-ILD.

Methods: This is a multicenter, retrospective, observational study of patients with RA-ILD. Clinical and radiological data from patients with RA-ILD were obtained from electronic medical records, including demographics, clinical characteristics, laboratory tests, pulmonary function tests, ECHO, and HRCT images.

Result: Out of 732 patients, 57 had RA-ILD. The mean age at the time of ILD diagnosis was 61.9 (± 12.2) years. RA-ILD diagnosis was significantly less among females (p = 0.008). Patients who ever smoked had significantly more RA-ILD (p < 0.001). Patients with RA-ILD were more likely to present with medical comorbidities, namely diabetes (p < 0.001), hypertension (p < 0.001), ischemic heart disease (p < 0.001), and osteoarthritis (p = 0.030). The multivariate analysis revealed that the age (OR: 1.035, 95% CI: 48.45-52.86, p = 0.0001); gender (OR: 2.581, CI: 1.77-1.86, p = 0.001), DM (OR: 2.498, 95% Cl: 1.65-1.76, P = 0.0001), HTN (OR: 1.975, 95% Cl: 1.61-1.74, P = 0.019), IHD (OR: 6.043, 95% Cl: 1.89-1.93, P = 0.0001) have a significant positive association with RA-ILD. No significant differences were observed between seropositive parameters with or without RA-ILD (p > 0.05). The most common symptoms of RA-ILD were cough (55.6%) and dyspnea (30.2%), and the most common ILD pattern was Non-specific Interstitial Pneumonia (NSIP) (55.6%) followed by Usual Interstitial Pneumonia (UIP) (38.9%). Traction bronchiectasis (75.5%) and glass ground opacities (73.6%) were also observed. The mean FVC and DLCO at baseline were 64.6% and 53.3%, respectively.

Conclusion: In this cohort of patients, Saudi RA-ILD patients had a predominant NSIP pattern conversely to what is seen globally. These findings could be explained by the lower rates of smoking in our patient population. Future prospective national studies are needed to confirm the current findings and better evaluate RA-ILD epidemiology and risk factors.

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来源期刊
BMC Rheumatology
BMC Rheumatology Medicine-Rheumatology
CiteScore
3.80
自引率
0.00%
发文量
73
审稿时长
15 weeks
期刊最新文献
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