Fabiana Perrone, Federica Pecci, Michele Maffezzoli, Giulia Claire Giudice, Valeria Cognigni, Giulia Mazzaschi, Luca Cantini, Luca Santamaria, Francesco Paoloni, Marco Luigi Bruno Rocchi, Matilde Coriano', Alessandro Acunzo, Federico Quaini, Marcello Tiseo, Saini S Kamal, Rossana Berardi, Sebastiano Buti
{"title":"中性粒细胞与淋巴细胞比率对接受免疫疗法的晚期癌症患者血脂状况的不同影响。","authors":"Fabiana Perrone, Federica Pecci, Michele Maffezzoli, Giulia Claire Giudice, Valeria Cognigni, Giulia Mazzaschi, Luca Cantini, Luca Santamaria, Francesco Paoloni, Marco Luigi Bruno Rocchi, Matilde Coriano', Alessandro Acunzo, Federico Quaini, Marcello Tiseo, Saini S Kamal, Rossana Berardi, Sebastiano Buti","doi":"10.1080/1750743X.2024.2377953","DOIUrl":null,"url":null,"abstract":"<p><p><b>Aim:</b> To investigate the different impact of each component of lipid profile in advanced cancer patients treated with immune checkpoints inhibitors (ICIs) according to neutrophil-to-lymphocyte ratio (NLR) value.<b>Methods:</b> We retrospectively collected total cholesterol (TC), triglycerides (TGs), low-density lipoproteins (LDL), high-density lipoproteins (HDL).<b>Results:</b> 407 patients were enrolled. In NLR <4 subgroup, TGs <150 mg/dl led to longer PFS (<i>p</i> = 0.01) and OS (<i>p</i> = 0.02) compared with TGs ≥150 mg/dl; LDL <100 mg/dl led to longer PFS (<i>p</i> = 0.004) and OS (<i>p</i> = 0.007) compared with LDL ≥100 mg/dl. In NLR ≥4 subgroup, TC >200 mg/dl led to longer PFS (<i>p</i> = 0.008) and OS (<i>p</i> = 0.004) compared with TC <200 mg/dl.<b>Conclusion:</b> We showed a distinct prognostic impact of lipid profile according to NLR.</p>","PeriodicalId":13328,"journal":{"name":"Immunotherapy","volume":" ","pages":"859-868"},"PeriodicalIF":2.7000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457594/pdf/","citationCount":"0","resultStr":"{\"title\":\"Differential impact of lipid profile according to neutrophil-to-lymphocyte ratio status in patients with advanced cancer treated with immunotherapy.\",\"authors\":\"Fabiana Perrone, Federica Pecci, Michele Maffezzoli, Giulia Claire Giudice, Valeria Cognigni, Giulia Mazzaschi, Luca Cantini, Luca Santamaria, Francesco Paoloni, Marco Luigi Bruno Rocchi, Matilde Coriano', Alessandro Acunzo, Federico Quaini, Marcello Tiseo, Saini S Kamal, Rossana Berardi, Sebastiano Buti\",\"doi\":\"10.1080/1750743X.2024.2377953\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Aim:</b> To investigate the different impact of each component of lipid profile in advanced cancer patients treated with immune checkpoints inhibitors (ICIs) according to neutrophil-to-lymphocyte ratio (NLR) value.<b>Methods:</b> We retrospectively collected total cholesterol (TC), triglycerides (TGs), low-density lipoproteins (LDL), high-density lipoproteins (HDL).<b>Results:</b> 407 patients were enrolled. In NLR <4 subgroup, TGs <150 mg/dl led to longer PFS (<i>p</i> = 0.01) and OS (<i>p</i> = 0.02) compared with TGs ≥150 mg/dl; LDL <100 mg/dl led to longer PFS (<i>p</i> = 0.004) and OS (<i>p</i> = 0.007) compared with LDL ≥100 mg/dl. In NLR ≥4 subgroup, TC >200 mg/dl led to longer PFS (<i>p</i> = 0.008) and OS (<i>p</i> = 0.004) compared with TC <200 mg/dl.<b>Conclusion:</b> We showed a distinct prognostic impact of lipid profile according to NLR.</p>\",\"PeriodicalId\":13328,\"journal\":{\"name\":\"Immunotherapy\",\"volume\":\" \",\"pages\":\"859-868\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457594/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Immunotherapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/1750743X.2024.2377953\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/8/6 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunotherapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/1750743X.2024.2377953","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/6 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
Differential impact of lipid profile according to neutrophil-to-lymphocyte ratio status in patients with advanced cancer treated with immunotherapy.
Aim: To investigate the different impact of each component of lipid profile in advanced cancer patients treated with immune checkpoints inhibitors (ICIs) according to neutrophil-to-lymphocyte ratio (NLR) value.Methods: We retrospectively collected total cholesterol (TC), triglycerides (TGs), low-density lipoproteins (LDL), high-density lipoproteins (HDL).Results: 407 patients were enrolled. In NLR <4 subgroup, TGs <150 mg/dl led to longer PFS (p = 0.01) and OS (p = 0.02) compared with TGs ≥150 mg/dl; LDL <100 mg/dl led to longer PFS (p = 0.004) and OS (p = 0.007) compared with LDL ≥100 mg/dl. In NLR ≥4 subgroup, TC >200 mg/dl led to longer PFS (p = 0.008) and OS (p = 0.004) compared with TC <200 mg/dl.Conclusion: We showed a distinct prognostic impact of lipid profile according to NLR.
期刊介绍：
Many aspects of the immune system and mechanisms of immunomodulatory therapies remain to be elucidated in order to exploit fully the emerging opportunities. Those involved in the research and clinical applications of immunotherapy are challenged by the huge and intricate volumes of knowledge arising from this fast-evolving field. The journal Immunotherapy offers the scientific community an interdisciplinary forum, providing them with information on the most recent advances of various aspects of immunotherapies, in a concise format to aid navigation of this complex field.
Immunotherapy delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this vitally important area of research. Unsolicited article proposals are welcomed and authors are required to comply fully with the journal''s Disclosure & Conflict of Interest Policy as well as major publishing guidelines, including ICMJE and GPP3.
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