伊沙福柳胺、伊普拉菌素和吡喹酮外用复方制剂对猫斑疹伤寒的疗效。

IF 2.3 2区 医学 Q2 PARASITOLOGY Parasite Pub Date : 2024-01-01 Epub Date: 2024-08-07 DOI:10.1051/parasite/2024044
Eric Tielemans, Carin Rautenbach, Zamantungwa Khumalo, Frederic Beugnet
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引用次数: 0

摘要

海湾蜱(Amblyomma maculatum)侵扰多种脊椎动物,包括家畜、狗、猫和人类。它是一种对兽医和公共卫生具有重要意义的物种,尤其是作为美国犬肝吸虫病或潮水斑疹热等疾病的传播媒介。我们进行了一项实验研究,以评估 NexGard® Combo(一种用于猫的局部杀寄生虫产品,结合了依普菌素、吡喹酮和埃沙福胺)对诱发的斑潜蝇感染的疗效。这项良好临床实践(GCP)研究采用了随机、阴性对照、掩蔽设计。十只猫被分配到未治疗组,十只猫被分配到治疗组,第 0 天按最小标签剂量用药一次。在第 2、7、14、21、28、35 和 42 天,用 ~50 只未喂食的成年斑潜蝇对猫进行侵袭。在第 3、10、17、24、31、38 和 45 天,即治疗后 72 小时和随后的侵染后,取出蜱虫并计数,然后使用每组中活的附着蜱虫数量计算药效。在每个时间点上,所有未经治疗的猫都有充分的感染,这表明蜱虫群的活力很强,研究模型也很充分。在治疗后 72 小时,单次施药对现有蜱虫侵扰的治愈率为 98.7%。在接下来的五周中,每周侵扰 72 小时后的预防效果为 93.8% 到 99.4%。
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Efficacy of a topical combination of esafoxolaner, eprinomectin and praziquantel against Amblyomma maculatum infestations in cats.

Amblyomma maculatum, the Gulf Coast tick, infests a wide range of vertebrate species including livestock, dogs, cats, and humans. It is a species of significant veterinary and public health importance, especially as a vector of diseases, for instance American canine hepatozoonosis or tidewater spotted fever. An experimental study was conducted to evaluate the efficacy of NexGard® Combo, a topical endectoparasiticide product for cats combining eprinomectin, praziquantel and esafoxolaner, against induced infestations of A. maculatum in cats. This Good Clinical Practice (GCP) study used a randomized, negative controlled, masked design. Ten cats were allocated to an untreated group and ten to a treated group, dosed once on Day 0 at the minimum label dose. On Days -2, 7, 14, 21, 28, 35, and 42, cats were infested with ~50 unfed adult A. maculatum. On Days 3, 10, 17, 24, 31, 38, and 45, i.e., 72 h after treatment and subsequent infestations, ticks were removed, counted and the numbers of live attached tick in each group were used for efficacy calculations. At each time-point, all untreated cats were adequately infested, demonstrating a vigorous tick population and an adequate study model. The curative efficacy after a single application against existing tick infestation, 72 h after treatment, was 98.7%. The preventive efficacy, 72 h after weekly infestations, over the following five weeks ranged from 93.8% to 99.4%.

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来源期刊
Parasite
Parasite 医学-寄生虫学
CiteScore
5.50
自引率
6.90%
发文量
49
审稿时长
3 months
期刊介绍: Parasite is an international open-access, peer-reviewed, online journal publishing high quality papers on all aspects of human and animal parasitology. Reviews, articles and short notes may be submitted. Fields include, but are not limited to: general, medical and veterinary parasitology; morphology, including ultrastructure; parasite systematics, including entomology, acarology, helminthology and protistology, and molecular analyses; molecular biology and biochemistry; immunology of parasitic diseases; host-parasite relationships; ecology and life history of parasites; epidemiology; therapeutics; new diagnostic tools. All papers in Parasite are published in English. Manuscripts should have a broad interest and must not have been published or submitted elsewhere. No limit is imposed on the length of manuscripts, but they should be concisely written. Papers of limited interest such as case reports, epidemiological studies in punctual areas, isolated new geographical records, and systematic descriptions of single species will generally not be accepted, but might be considered if the authors succeed in demonstrating their interest.
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