核生物分子凝聚体的机械重塑。

IF 5.3 2区 医学 Q1 PHYSIOLOGY Physiology Pub Date : 2025-01-01 Epub Date: 2024-08-07 DOI:10.1152/physiol.00027.2024
Giulia Soggia, Yasmin ElMaghloob, Annie-Kermen Boromangnaeva, Adel Al Jord
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引用次数: 0

摘要

生物体的健康依赖于细胞的增殖、迁移和分化。这些普遍过程依赖于细胞质的重组,主要由细胞骨架及其产生力的马达驱动。它们的活动产生的力能机械地搅动细胞核及其内部。生殖细胞生物学的新证据显示,这些细胞骨架力可以被调整,以重塑无核膜的隔室(即生物分子凝聚体),并调节它们的 RNA 处理功能,从而使对生育至关重要的后续细胞分裂取得成功。细胞骨架和核凝聚物的重组在许多生理和病理情况下都很常见,这使得核凝聚物的机械重塑可能成为调节其功能的一种更广泛的机制。在此,我们回顾了这一新发现的凝集素重塑机制,并大胆探讨了与之相关的健康和疾病背景,重点关注生殖、癌症和早衰。
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Mechanical Remodeling of Nuclear Biomolecular Condensates.

Organism health relies on cell proliferation, migration, and differentiation. These universal processes depend on cytoplasmic reorganization driven notably by the cytoskeleton and its force-generating motors. Their activity generates forces that mechanically agitate the cell nucleus and its interior. New evidence from reproductive cell biology revealed that these cytoskeletal forces can be tuned to remodel nuclear membraneless compartments, known as biomolecular condensates, and regulate their RNA processing function for the success of subsequent cell division that is critical for fertility. Both cytoskeletal and nuclear condensate reorganization are common to numerous physiological and pathological contexts, raising the possibility that mechanical remodeling of nuclear condensates may be a much broader mechanism regulating their function. Here, we review this newfound mechanism of condensate remodeling and venture into the contexts of health and disease where it may be relevant, with a focus on reproduction, cancer, and premature aging.

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来源期刊
Physiology
Physiology 医学-生理学
CiteScore
14.50
自引率
0.00%
发文量
37
期刊介绍: Physiology journal features meticulously crafted review articles penned by esteemed leaders in their respective fields. These articles undergo rigorous peer review and showcase the forefront of cutting-edge advances across various domains of physiology. Our Editorial Board, comprised of distinguished leaders in the broad spectrum of physiology, convenes annually to deliberate and recommend pioneering topics for review articles, as well as select the most suitable scientists to author these articles. Join us in exploring the forefront of physiological research and innovation.
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