CoLaus队列中慢性疼痛发病和康复的相关因素。

IF 3.5 2区 医学 Q1 ANESTHESIOLOGY European Journal of Pain Pub Date : 2024-08-07 DOI:10.1002/ejp.4712
Giada Dirupo, Jean-Benoît Rossel, Nicolas Fournier, Audrey D'Andrea, Peter Vollenweider, Isabelle Decosterd, Marc René Suter, Chantal Berna
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引用次数: 0

摘要

研究背景以往只有少数队列研究同时研究了慢性疼痛(CP)发病和恢复的预测因素。此外,这些研究使用了不同的社会人口学特征和疼痛相关特征,没有对睡眠和抑郁进行标准化测量。本研究旨在扩大和加强在大量瑞士人群中的这些发现:我们分析了瑞士洛桑一个纵向队列(n = 4602)的数据,这些数据是在相隔 5 年的两个时间点收集的。我们通过两个独立的多变量逻辑回归模型研究了CP发病和恢复的预测因素,包括社会人口数据以及睡眠和情绪的标准化测量:43.1%和44.4%的参与者报告了慢性疼痛,11.6%的参与者在第二次随访时报告了中度或重度疼痛。神经性疼痛(无论强度如何)对生活质量的负面影响更大。推理模型(n = 1331)发现,男性是CP康复的预测因素。年龄较大、超重或肥胖(与正常体重相比)、抑郁评分较高和服用止痛药物可预测第二次随访时的持续疼痛。第二个模型(n = 1886)发现,超重或肥胖(与正常体重相比)、睡眠质量低和曾经吸烟(与不吸烟者相比)可预测患上心绞痛的风险,而男性可降低患上心绞痛的风险:结论:虽然性别和体重与心绞痛的恢复和新发都有关系,但在这些过程中也需要考虑不同的变量,根据预防或治疗的具体情况,强调需要解决的特定因素:瑞士队列(N = 4602)中的多变量模型显示,男性、未服用止痛药、体重正常、抑郁评分较低和年龄较小与慢性疼痛的恢复有关,而女性、肥胖或超重、睡眠质量较差和曾经吸烟则与新的慢性疼痛发作有关。在治疗和预防工作中,需要考虑这些共同的和独立的因素。
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Correlates of chronic pain onset and recovery in the CoLaus cohort.

Background: Only few previous cohort studies examined simultaneously predictors of chronic pain (CP) onset and recovery. Furthermore, these studies used various sociodemographic and pain-related characteristics, without standardized measures of sleep and depression. The present study aimed at expanding and strengthening these findings in a large Swiss population.

Methods: We analysed data from a longitudinal cohort (n = 4602) collected at two time points separated by 5 years in Lausanne, Switzerland. We studied through two independent multivariable logistic regression models, the predictors of CP onset and recovery, including socio-demographic data as well as standardized measures of sleep and mood.

Results: Chronic pain was reported by 43.1% and 44.4% of participants, with 11.6% at the second follow-up reporting moderate or intense pain. Neuropathic pain, regardless of intensity, had a more negative impact on quality of life. An inferential model (n = 1331) identified the male sex as predictive for recovering from CP. Older age, being overweight or obese (compared to normal weight), higher depression scores and pain medication intake were predictive for sustained pain at the second follow-up. A second model (n = 1886) identified being overweight or obese (compared to normal weight), low quality of sleep and being a former smoker (compared to a non-smoker) as predictive for developing CP, while the male sex was lowering the risk.

Conclusions: While sex and weight are associated with both recovery and new CP onset, separate variables also need to be considered in these processes, underlining specific factors to be addressed, depending on the context, whether preventive or therapeutic.

Significance statement: Multivariable models in a Swiss cohort (N = 4602) associate male sex, not taking pain medication, normal weight, lower depression scores and younger age with recovery from chronic pain, while females, obese or overweight, having worse sleep and former smokers are associated with onset of new chronic pain. These common and separate factors need to be considered in treatment and prevention efforts.

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来源期刊
European Journal of Pain
European Journal of Pain 医学-临床神经学
CiteScore
7.50
自引率
5.60%
发文量
163
审稿时长
4-8 weeks
期刊介绍: European Journal of Pain (EJP) publishes clinical and basic science research papers relevant to all aspects of pain and its management, including specialties such as anaesthesia, dentistry, neurology and neurosurgery, orthopaedics, palliative care, pharmacology, physiology, psychiatry, psychology and rehabilitation; socio-economic aspects of pain are also covered. Regular sections in the journal are as follows: • Editorials and Commentaries • Position Papers and Guidelines • Reviews • Original Articles • Letters • Bookshelf The journal particularly welcomes clinical trials, which are published on an occasional basis. Research articles are published under the following subject headings: • Neurobiology • Neurology • Experimental Pharmacology • Clinical Pharmacology • Psychology • Behavioural Therapy • Epidemiology • Cancer Pain • Acute Pain • Clinical Trials.
期刊最新文献
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