用于诊断肺部和肺部外结核病的真菌检测评估:系统综述和荟萃分析。

IF 4.2 2区 医学 Q1 INFECTIOUS DISEASES Expert Review of Anti-infective Therapy Pub Date : 2024-08-01 Epub Date: 2024-08-11 DOI:10.1080/14787210.2024.2389876
Shima Mahmoudi, Amir Hossein Sadegh Moghaddasi
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引用次数: 0

摘要

背景:结核病(TB)仍然是全球关注的重大健康问题,需要准确及时的诊断方法。本研究旨在进行系统综述和荟萃分析,以评估 Truenat 检测法对肺结核(PTB)和肺外结核(EPTB)的诊断准确性:方法:系统检索了PubMed、Scopus和Web of Science网站上比较Truenat测定与结核分枝杆菌确证方法的研究:将特鲁纳 MTB 检测法与洛文斯坦-詹森(LJ)培养法进行比较,汇总的敏感性和特异性分别为 86% (95% CI: 79-91%) 和 86% (95% CI: 82-90%)。分枝杆菌生长指示管(MGIT)培养的汇总敏感性为 88%(95% CI:82-92%),特异性为 79%(95% CI:57-92%)。与涂片显微镜检查相比,Truenat 检测法的集合灵敏度和特异性分别为 92% (95% CI: 78-98%) 和 86% (95% CI: 64-95%)。与 Xpert MTB/RIF 相比,Truenat 检测方法在检测 PTB 方面的集合灵敏度为 92% (95% CI: 80-97%),集合特异性为 92% (95% CI: 56-99%);在诊断 EPTB 方面的集合灵敏度为 94% (95% CI: 81-98%),特异性为 77% (95% CI: 32-96%):本研究强调了 Truenat 检测作为诊断 PTB 和 EPTB 的重要工具的潜力:CRD42024526686。
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Evaluation of truenat assays for the diagnosis of pulmonary and extrapulmonary tuberculosis: a systematic review and meta-analysis.

Background: Tuberculosis (TB) remains a significant global health concern, necessitating accurate and timely diagnostic methods. This study aimed to conduct a systematic review and meta-analysis to assess the diagnostic accuracy of Truenat assays for both pulmonary TB (PTB) and extrapulmonary TB (EPTB).

Method: PubMed, Scopus, and Web of Science were systematically searched for studies comparing Truenat assays to Mycobacterium tuberculosis confirmation methods.

Results: Comparing Truenat MTB assay with the Lowenstein-Jensen (LJ) culture, the pooled sensitivity and specificity were 86% (95% CI: 79-91%) and 86% (95% CI: 82-90%), respectively. For Mycobacterial Growth Indicator Tube (MGIT) culture comparison, pooled sensitivity was 88% (95% CI: 82-92%) with a specificity of 79% (95% CI: 57-92%). Compared to smear microscopy, Truenat assays displayed pooled sensitivity and specificity of 92% (95% CI: 78-98%) and 86% (95% CI: 64-95%). In comparison to Xpert MTB/RIF, Truenat assays exhibited a pooled sensitivity of 92% (95% CI: 80-97%) and a pooled specificity of 92% (95% CI: 56-99%) for PTB detection, and a pooled sensitivity of 94% (95% CI: 81-98%) and a specificity of 77% (95% CI: 32-96%) for the diagnosis of EPTB.

Conclusion: This study underscores the potential of Truenat assays as valuable tools for diagnosing both PTB and EPTB.

Prospero id: CRD42024526686.

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来源期刊
CiteScore
11.20
自引率
0.00%
发文量
66
审稿时长
4-8 weeks
期刊介绍: Expert Review of Anti-Infective Therapy (ISSN 1478-7210) provides expert reviews on therapeutics and diagnostics in the treatment of infectious disease. Coverage includes antibiotics, drug resistance, drug therapy, infectious disease medicine, antibacterial, antimicrobial, antifungal and antiviral approaches, and diagnostic tests.
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