外泌体:胰腺癌进展的新见解。

IF 8.2 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY International Journal of Biological Sciences Pub Date : 2024-08-01 eCollection Date: 2024-01-01 DOI:10.7150/ijbs.97076
Xulin Zhou, Yongmin Yan, Ye Shen, Min Xu, Wenrong Xu
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引用次数: 0

摘要

胰腺癌是一种侵袭性极强的致命恶性肿瘤,治疗方法少,预后差。了解驱动其生长的分子途径对于制定有效的治疗策略至关重要。外泌体是由多种类型细胞分泌的小型细胞外囊泡,近来已成为细胞间重要的通讯介质,对肿瘤的生长和转移具有影响。我们讨论了外泌体的生物发生和特征,以及它们在肿瘤生长、免疫逃避、血管生成、侵袭和转移中的载体和功能意义。我们进一步强调了外泌体作为胰腺癌诊断生物标记物和治疗靶点的潜力。最后,我们讨论了利用外泌体改善胰腺癌患者预后的挑战和未来前景。
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Exosomes: Emerging Insights into the Progression of Pancreatic Cancer.

Pancreatic cancer is a very aggressive and fatal malignancy with few therapeutic choices and a poor prognosis. Understanding the molecular pathways that drive its growth is critical for developing effective therapeutic strategies. Exosomes, small extracellular vesicles secreted by numerous cell types, have recently emerged as essential intercellular communication mediators, with implications for tumor growth and metastasis. In this article, we present a review of current knowledge about exosomes and their role in pancreatic cancer progression We discuss the biogenesis and characteristics of exosomes, as well as their cargo and functional significance in tumor growth, immune evasion, angiogenesis, invasion, and metastasis. We further emphasize the potential of exosomes as diagnostic biomarkers and therapeutic targets for pancreatic cancer. Finally, we discuss the challenges and future perspectives in using exosomes to improve patient outcomes in pancreatic cancer.

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来源期刊
International Journal of Biological Sciences
International Journal of Biological Sciences 生物-生化与分子生物学
CiteScore
16.90
自引率
1.10%
发文量
413
审稿时长
1 months
期刊介绍: The International Journal of Biological Sciences is a peer-reviewed, open-access scientific journal published by Ivyspring International Publisher. It dedicates itself to publishing original articles, reviews, and short research communications across all domains of biological sciences.
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