视网膜作为阿尔茨海默氏症早期阶段的潜在生物标志物。

IF 4.4 2区 医学 Q1 CLINICAL NEUROLOGY Annals of Clinical and Translational Neurology Pub Date : 2024-08-09 DOI:10.1002/acn3.52172
Rong Gao, Huan Luo, Su Yan, Li Ba, Sirui Peng, Bitao Bu, Xufang Sun, Min Zhang
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引用次数: 0

摘要

目的描述主观认知功能减退(SCD)患者视网膜微血管和结构的特征,并确定阿尔茨海默病(AD)早期的潜在生物标志物:本研究共纳入了 35 名 SCD 患者、36 名认知障碍患者和 29 名认知正常(NC)患者。采用光学相干断层血管造影术评估视网膜血管密度、眼窝无血管区面积和视网膜厚度。比较了三组患者的视网膜灌注和结构参数。此外,还分析了SCD阶段视网膜参数、脑血流(CBF)和外周血生物标志物之间的关联:结果:与NC相比,SCD患者黄斑部浅层血管复合体(SVC)血管密度和毛细血管周围视网膜神经纤维层厚度明显降低。此外,SCD 患者黄斑神经节细胞复合体厚度与 CBF 呈正相关:SCD患者的视网膜微血管和结构发生了改变。黄斑神经节细胞复合体厚度与脑灌注相关。视网膜具有作为早期检测 AD 的新型生物标记物的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Retina as a potential biomarker for the early stage of Alzheimer's disease spectrum

Objective

To characterize the retinal microvasculature and structure in subjective cognitive decline (SCD) and identify the potential biomarker for the early stage of the Alzheimer's disease (AD) spectrum.

Methods

In this study, 35 patients with SCD, 36 with cognitive impairment, and 29 with normal cognition (NC) were enrolled. Optical coherence tomography angiography was employed to assess retinal vascular density, fovea avascular zone area, and retinal thickness. The parameters reflecting retinal perfusion and structure were compared among the three groups. In addition, the association between retinal parameters, cerebral blood flow (CBF), and peripheral blood biomarkers in the SCD stage was analyzed.

Results

The superficial vascular complex (SVC) vascular density in the macula and retinal nerve fiber layer thickness in the peripapillary were significantly reduced in individuals with SCD compared to NC. Furthermore, there was a positive correlation between macular ganglion cell complex thickness and CBF in SCD.

Interpretation

The retinal microvasculature and structure exhibit alterations in individuals with SCD. Macular ganglion cell complex thickness demonstrates correlations with cerebral perfusion. The retina holds potential as a novel biomarker for early detection of AD.

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来源期刊
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology Medicine-Neurology (clinical)
CiteScore
9.10
自引率
1.90%
发文量
218
审稿时长
8 weeks
期刊介绍: Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.
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