Mpox、性传播感染和综合预防:巴西里约热内卢一个主要队列的启示。

IF 3.4 2区 医学 Q3 IMMUNOLOGY AIDS Pub Date : 2024-11-01 Epub Date: 2024-08-12 DOI:10.1097/QAD.0000000000003991
Mayara S T Silva, Thiago S Torres, Carolina Coutinho, Emilia M Jalil, Carolyn Yanavich, Pedro S Martins, Matheus O Bastos, Maira B Mesquita, Amanda Echeverría-Guevara, Sandro Nazer, Eduardo M Peixoto, Marcela Terra, Ana Lovetro, Paula P S Reges, Maria Roberta Meneguetti, Ronaldo I Moreira, Flavia C S Lessa, Brenda Hoagland, Estevão P Nunes, Sandra Wagner Cardoso, Valdilea G Veloso, Beatriz Grinsztejn
{"title":"Mpox、性传播感染和综合预防:巴西里约热内卢一个主要队列的启示。","authors":"Mayara S T Silva, Thiago S Torres, Carolina Coutinho, Emilia M Jalil, Carolyn Yanavich, Pedro S Martins, Matheus O Bastos, Maira B Mesquita, Amanda Echeverría-Guevara, Sandro Nazer, Eduardo M Peixoto, Marcela Terra, Ana Lovetro, Paula P S Reges, Maria Roberta Meneguetti, Ronaldo I Moreira, Flavia C S Lessa, Brenda Hoagland, Estevão P Nunes, Sandra Wagner Cardoso, Valdilea G Veloso, Beatriz Grinsztejn","doi":"10.1097/QAD.0000000000003991","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the prevalence and characteristics of concurrent bacterial sexually transmitted infections (bSTIs) among individuals with mpox.</p><p><strong>Design: </strong>Prospective cohort study of participants aged 18 years or older with confirmed mpox conducted in Rio de Janeiro, Brazil. This cross-sectional analysis includes only participants who underwent bSTI testing at baseline between June 2022 and January 2024.</p><p><strong>Methods: </strong>Participants were offered testing for chlamydia/gonorrhea (NAAT, anorectal swabs) and syphilis (active diagnosis if VDRL ≥ 1/8). Baseline prevalence of bSTIs was calculated, and participant characteristics were described based on concomitant bSTI diagnosis (yes/no). Chi-squared/Fisher's tests were used for qualitative variables, and the Wilcoxon rank-sum test for quantitative variables.</p><p><strong>Results: </strong>Out of 634 enrolled participants, 538 (84.9%) were tested for STIs and included in this analysis, mostly cisgender men, aged 30-39 years with postsecondary education. Overall prevalence of concomitant bSTI was 37.3%, mainly syphilis, followed by chlamydia and gonorrhea. Half of the participants were living with HIV, and one third was on HIV pre-exposure prophylaxis. Concomitant bSTI diagnosis at the time of mpox assessment was associated with being aged 30-39 years, self-identifying as cisgender men, having HIV-positive status, reporting proctitis symptoms and reporting any STI in the past 12 months.</p><p><strong>Conclusions: </strong>Our data reveals a notable prevalence of concomitant bSTIs among participants with confirmed mpox at a prominent infectious diseases' referral center in Rio de Janeiro, Brazil. These findings underscore the importance of integrating mpox into the differential diagnosis of anogenital manifestations and the promotion of combination prevention strategies within sexual healthcare services.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424052/pdf/","citationCount":"0","resultStr":"{\"title\":\"Mpox, sexually transmitted infections and combination prevention: insights from a major cohort in Rio de Janeiro, Brazil.\",\"authors\":\"Mayara S T Silva, Thiago S Torres, Carolina Coutinho, Emilia M Jalil, Carolyn Yanavich, Pedro S Martins, Matheus O Bastos, Maira B Mesquita, Amanda Echeverría-Guevara, Sandro Nazer, Eduardo M Peixoto, Marcela Terra, Ana Lovetro, Paula P S Reges, Maria Roberta Meneguetti, Ronaldo I Moreira, Flavia C S Lessa, Brenda Hoagland, Estevão P Nunes, Sandra Wagner Cardoso, Valdilea G Veloso, Beatriz Grinsztejn\",\"doi\":\"10.1097/QAD.0000000000003991\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To evaluate the prevalence and characteristics of concurrent bacterial sexually transmitted infections (bSTIs) among individuals with mpox.</p><p><strong>Design: </strong>Prospective cohort study of participants aged 18 years or older with confirmed mpox conducted in Rio de Janeiro, Brazil. This cross-sectional analysis includes only participants who underwent bSTI testing at baseline between June 2022 and January 2024.</p><p><strong>Methods: </strong>Participants were offered testing for chlamydia/gonorrhea (NAAT, anorectal swabs) and syphilis (active diagnosis if VDRL ≥ 1/8). Baseline prevalence of bSTIs was calculated, and participant characteristics were described based on concomitant bSTI diagnosis (yes/no). Chi-squared/Fisher's tests were used for qualitative variables, and the Wilcoxon rank-sum test for quantitative variables.</p><p><strong>Results: </strong>Out of 634 enrolled participants, 538 (84.9%) were tested for STIs and included in this analysis, mostly cisgender men, aged 30-39 years with postsecondary education. Overall prevalence of concomitant bSTI was 37.3%, mainly syphilis, followed by chlamydia and gonorrhea. Half of the participants were living with HIV, and one third was on HIV pre-exposure prophylaxis. Concomitant bSTI diagnosis at the time of mpox assessment was associated with being aged 30-39 years, self-identifying as cisgender men, having HIV-positive status, reporting proctitis symptoms and reporting any STI in the past 12 months.</p><p><strong>Conclusions: </strong>Our data reveals a notable prevalence of concomitant bSTIs among participants with confirmed mpox at a prominent infectious diseases' referral center in Rio de Janeiro, Brazil. These findings underscore the importance of integrating mpox into the differential diagnosis of anogenital manifestations and the promotion of combination prevention strategies within sexual healthcare services.</p>\",\"PeriodicalId\":7502,\"journal\":{\"name\":\"AIDS\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424052/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"AIDS\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/QAD.0000000000003991\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/8/12 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"AIDS","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/QAD.0000000000003991","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/12 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

目的评估并发细菌性性传播感染(bSTIs)在麻风病患者中的流行率和特征:前瞻性队列研究:在巴西里约热内卢对 18 岁或 18 岁以上确诊为 mpox 的参与者进行研究。这项横断面分析仅包括在 2022 年 6 月至 2024 年 1 月期间接受 bSTI 基线检测的参与者:为参与者提供衣原体/淋病(NAAT,肛门直肠拭子)和梅毒(VDRL≥1/8时为主动诊断)检测。根据 bSTI 诊断(是/否)计算 bSTI 的基线流行率,并描述参与者的特征。定性变量采用卡方/菲舍尔检验,定量变量采用 Wilcoxon 秩和检验:在 634 名注册参与者中,有 538 人(84.9%)接受了性传播感染检测并被纳入本次分析,他们大多为男性,年龄在 30-39 岁之间,受过高等教育。并发 bSTI 的总体流行率为 37.3%,主要是梅毒,其次是衣原体和淋病。半数参与者合并有艾滋病病毒感染,三分之一的人正在接受 PrEP 治疗。在进行 mpox 评估时同时诊断出 bSTI 与年龄在 30-39 岁之间、自我认同为顺性男性、HIV 阳性、报告直肠炎症状以及在过去 12 个月中报告过任何 STI 相关:我们的数据显示,在巴西里约热内卢一家知名传染病转诊中心确诊为麻风病的患者中,并发性传播感染的发病率很高。这些发现强调了将肛门疱疹纳入肛门生殖器表现的鉴别诊断以及在性保健服务中推广综合预防策略的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Mpox, sexually transmitted infections and combination prevention: insights from a major cohort in Rio de Janeiro, Brazil.

Objective: To evaluate the prevalence and characteristics of concurrent bacterial sexually transmitted infections (bSTIs) among individuals with mpox.

Design: Prospective cohort study of participants aged 18 years or older with confirmed mpox conducted in Rio de Janeiro, Brazil. This cross-sectional analysis includes only participants who underwent bSTI testing at baseline between June 2022 and January 2024.

Methods: Participants were offered testing for chlamydia/gonorrhea (NAAT, anorectal swabs) and syphilis (active diagnosis if VDRL ≥ 1/8). Baseline prevalence of bSTIs was calculated, and participant characteristics were described based on concomitant bSTI diagnosis (yes/no). Chi-squared/Fisher's tests were used for qualitative variables, and the Wilcoxon rank-sum test for quantitative variables.

Results: Out of 634 enrolled participants, 538 (84.9%) were tested for STIs and included in this analysis, mostly cisgender men, aged 30-39 years with postsecondary education. Overall prevalence of concomitant bSTI was 37.3%, mainly syphilis, followed by chlamydia and gonorrhea. Half of the participants were living with HIV, and one third was on HIV pre-exposure prophylaxis. Concomitant bSTI diagnosis at the time of mpox assessment was associated with being aged 30-39 years, self-identifying as cisgender men, having HIV-positive status, reporting proctitis symptoms and reporting any STI in the past 12 months.

Conclusions: Our data reveals a notable prevalence of concomitant bSTIs among participants with confirmed mpox at a prominent infectious diseases' referral center in Rio de Janeiro, Brazil. These findings underscore the importance of integrating mpox into the differential diagnosis of anogenital manifestations and the promotion of combination prevention strategies within sexual healthcare services.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
AIDS
AIDS 医学-病毒学
CiteScore
5.90
自引率
5.30%
发文量
478
审稿时长
3 months
期刊介绍: ​​​​​​​​​​​​​​​​​Publishing the very latest ground breaking research on HIV and AIDS. Read by all the top clinicians and researchers, AIDS has the highest impact of all AIDS-related journals. With 18 issues per year, AIDS guarantees the authoritative presentation of significant advances. The Editors, themselves noted international experts who know the demands of your work, are committed to making AIDS the most distinguished and innovative journal in the field. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.
期刊最新文献
Weight excess and obesity are associated with binge-eating behaviours in people with HIV. Association of T-cell subtypes with macrophage-specific arterial infiltration in people with HIV. The impact of diabetes mellitus on HIV virologic control: results of the MACS/WIHS combined cohort study. Fetal, neonatal, and infant death among offspring of pregnant women with HIV in Tanzania. A point-of-care tenofovir urine test improves accuracy of self-reported preexposure prophylaxis adherence and increases condomless sex reporting among young women.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1