评估儿童期系统性红斑狼疮患者的甲状腺功能障碍:桥本氏甲状腺炎的风险因素

IF 1.9 4区 医学 Q3 RHEUMATOLOGY Lupus Pub Date : 2024-10-01 Epub Date: 2024-08-09 DOI:10.1177/09612033241272964
Elif Kilic Konte, Hasan Karakas, Nergis Akay, Umit Gul, Kubra Ucak, Gurkan Tarcin, Esma Aslan, Aybuke Gunalp, Fatih Haslak, Oya Koker Turan, Mehmet Yildiz, Hande Turan, Ayse Kalyoncu Ucar, Amra Adrovic, Kenan Barut, Olcay Evliyaoglu, Sezgin Sahin, Ozgur Kasapcopur
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引用次数: 0

摘要

目的:有多项研究报道,在儿童期发病的系统性红斑狼疮(cSLE)患者中,自身免疫性甲状腺疾病,尤其是桥本氏甲状腺炎(HT)的发病率增加。我们的研究旨在调查甲状腺功能障碍和甲状腺炎在系统性红斑狼疮患者中的发病率和诱因:方法:横断面采集系统性红斑狼疮患者的甲状腺功能检测结果。方法:对系统性红斑狼疮患者进行横断面甲状腺功能检测,并从病历中收集人口统计学、临床和实验室特征以及活动评分。将确诊为系统性红斑狼疮的患者与健康对照组的甲状腺功能障碍频率进行比较。采用曼-惠特尼U检验、独立样本t检验、卡方检验或费雪精确检验来比较研究组。P值低于0.05为具有统计学意义:在73名系统性红斑狼疮患者中,14人(19.1%)患有亚临床甲状腺功能减退症,9人(12.3%)患有临床甲状腺功能减退症,12人(16.4%)被确诊为甲亢,12人(16.4%)有甲亢家族史。5 名甲状腺功能正常的患者和 1 名甲状腺自身抗体阳性的边缘亚临床甲减患者接受了甲状腺 USG 检查,结果显示甲状腺弥漫性异型回声增大。有甲状腺功能减退症和无甲状腺功能减退症的两组患者在临床和实验室数据或用药方面没有明显差异;但是,有甲状腺功能减退症的患者患有临床甲状腺功能减退症和有甲状腺功能减退症家族史的频率更高。确诊为甲亢的患者泼尼松龙累积剂量明显较低。与健康对照组相比,狼疮患者发生甲亢的频率要高得多:结果表明,即使是甲状腺功能正常的系统性红斑狼疮患者,其高血脂症的发病率也会增加,因此建议对系统性红斑狼疮患者进行更频繁的筛查。
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Evaluation of thyroid dysfunction in childhood-onset systemic lupus erythematosus: Risk factors for Hashimoto's thyroiditis.

Objective: Increased frequency of autoimmune thyroid disease, particularly Hashimoto's thyroiditis (HT) was reported several studies in the literature, in individuals with childhood-onset systemic lupus erythematosus (cSLE). Our study aimed to investigate the prevalence and contributing factors of thyroid dysfunction and HT among cSLE patients.

Methods: Thyroid function tests were obtained cross-sectionally from cSLE patients. Demographic, clinical, and laboratory characteristics and activity scores were collected from medical records. Patients diagnosed with cSLE were compared to the healthy control group for the frequency of thyroid dysfunction. The Mann-Whitney U, independent samples t test, and the Chi-square or Fisher's exact test were used to compare study groups. A p-value below 0.05 was considered statistically significant.

Results: Out of 73 cSLE patients, 14 (19.1%) had subclinical hypothyroidism, 9 (12.3%) had clinical hypothyroidism, 12 (16.4%) were diagnosed with HT, and 12 (16.4%) had a family history of HT. Thyroid USG was performed in 5 euthyroid patients and 1 borderline subclinical hypothyroid patient with positive thyroid autoantibody and reported as diffuse heterogeneous echogenicity enlargement in the thyroid gland. There were no significant differences in clinical and laboratory data or medication used between the groups with and without HT; however, patients with HT had a higher frequency of clinical hypothyroidism and family history of HT. Cumulative prednisolone dose was significantly lower in patients diagnosed with HT. The frequency of HT was considerably higher in patients with cSLE compared to the healthy control group.

Conclusion: The results demonstrate an increased incidence of HT in cSLE patients, even if they are euthyroid, and recommend that cSLE patients be screened more frequently.

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来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
期刊最新文献
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