Yulong Liu, Gang Zhai, Jingzhi Su, Yulong Gong, Binyuan Yang, Qisheng Lu, Longwei Xi, Yutong Zheng, Jingyue Cao, Haokun Liu, Junyan Jin, Zhimin Zhang, Yunxia Yang, Xiaoming Zhu, Zhongwei Wang, Gaorui Gong, Jie Mei, Zhan Yin, Rodolphe E. Gozlan, Shouqi Xie, Dong Han
{"title":"中国长口鲇基因组为了解食肉动物的摄食偏好和相应的代谢策略提供了新的视角","authors":"Yulong Liu, Gang Zhai, Jingzhi Su, Yulong Gong, Binyuan Yang, Qisheng Lu, Longwei Xi, Yutong Zheng, Jingyue Cao, Haokun Liu, Junyan Jin, Zhimin Zhang, Yunxia Yang, Xiaoming Zhu, Zhongwei Wang, Gaorui Gong, Jie Mei, Zhan Yin, Rodolphe E. Gozlan, Shouqi Xie, Dong Han","doi":"10.1101/gr.278476.123","DOIUrl":null,"url":null,"abstract":"Fish show variation in feeding habits to adapt to complex environments. However, the genetic basis of feeding preference and the corresponding metabolic strategies that differentiate feeding habits remain elusive. Here, by comparing the whole genome of a typical carnivorous fish (<em>Leiocassis longirostris</em> Günther) with that of herbivorous fish, we identify 250 genes through both positive selection and rapid evolution, including taste receptor <em>taste receptor type 1 member 3</em> (<em>tas1r3</em>) and <em>trypsin</em>. We demonstrate that <em>tas1r3</em> is required for carnivore preference in <em>tas1r3</em>-deficient zebrafish and in a diet-shifted grass carp model. We confirm that trypsin correlates with the metabolic strategies of fish with distinct feeding habits. Furthermore, marked alterations in trypsin activity and metabolic profiles are accompanied by a transition of feeding preference in <em>tas1r3</em>-deficient zebrafish and diet-shifted grass carp. Our results reveal a conserved adaptation between feeding preference and corresponding metabolic strategies in fish, and provide novel insights into the adaptation of feeding habits over the evolution course.","PeriodicalId":12678,"journal":{"name":"Genome research","volume":"83 1","pages":""},"PeriodicalIF":6.2000,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Chinese longsnout catfish genome provides novel insights into the feeding preference and corresponding metabolic strategy of carnivores\",\"authors\":\"Yulong Liu, Gang Zhai, Jingzhi Su, Yulong Gong, Binyuan Yang, Qisheng Lu, Longwei Xi, Yutong Zheng, Jingyue Cao, Haokun Liu, Junyan Jin, Zhimin Zhang, Yunxia Yang, Xiaoming Zhu, Zhongwei Wang, Gaorui Gong, Jie Mei, Zhan Yin, Rodolphe E. Gozlan, Shouqi Xie, Dong Han\",\"doi\":\"10.1101/gr.278476.123\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Fish show variation in feeding habits to adapt to complex environments. However, the genetic basis of feeding preference and the corresponding metabolic strategies that differentiate feeding habits remain elusive. Here, by comparing the whole genome of a typical carnivorous fish (<em>Leiocassis longirostris</em> Günther) with that of herbivorous fish, we identify 250 genes through both positive selection and rapid evolution, including taste receptor <em>taste receptor type 1 member 3</em> (<em>tas1r3</em>) and <em>trypsin</em>. We demonstrate that <em>tas1r3</em> is required for carnivore preference in <em>tas1r3</em>-deficient zebrafish and in a diet-shifted grass carp model. We confirm that trypsin correlates with the metabolic strategies of fish with distinct feeding habits. Furthermore, marked alterations in trypsin activity and metabolic profiles are accompanied by a transition of feeding preference in <em>tas1r3</em>-deficient zebrafish and diet-shifted grass carp. Our results reveal a conserved adaptation between feeding preference and corresponding metabolic strategies in fish, and provide novel insights into the adaptation of feeding habits over the evolution course.\",\"PeriodicalId\":12678,\"journal\":{\"name\":\"Genome research\",\"volume\":\"83 1\",\"pages\":\"\"},\"PeriodicalIF\":6.2000,\"publicationDate\":\"2024-08-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Genome research\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1101/gr.278476.123\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Genome research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1101/gr.278476.123","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
The Chinese longsnout catfish genome provides novel insights into the feeding preference and corresponding metabolic strategy of carnivores
Fish show variation in feeding habits to adapt to complex environments. However, the genetic basis of feeding preference and the corresponding metabolic strategies that differentiate feeding habits remain elusive. Here, by comparing the whole genome of a typical carnivorous fish (Leiocassis longirostris Günther) with that of herbivorous fish, we identify 250 genes through both positive selection and rapid evolution, including taste receptor taste receptor type 1 member 3 (tas1r3) and trypsin. We demonstrate that tas1r3 is required for carnivore preference in tas1r3-deficient zebrafish and in a diet-shifted grass carp model. We confirm that trypsin correlates with the metabolic strategies of fish with distinct feeding habits. Furthermore, marked alterations in trypsin activity and metabolic profiles are accompanied by a transition of feeding preference in tas1r3-deficient zebrafish and diet-shifted grass carp. Our results reveal a conserved adaptation between feeding preference and corresponding metabolic strategies in fish, and provide novel insights into the adaptation of feeding habits over the evolution course.
期刊介绍:
Launched in 1995, Genome Research is an international, continuously published, peer-reviewed journal that focuses on research that provides novel insights into the genome biology of all organisms, including advances in genomic medicine.
Among the topics considered by the journal are genome structure and function, comparative genomics, molecular evolution, genome-scale quantitative and population genetics, proteomics, epigenomics, and systems biology. The journal also features exciting gene discoveries and reports of cutting-edge computational biology and high-throughput methodologies.
New data in these areas are published as research papers, or methods and resource reports that provide novel information on technologies or tools that will be of interest to a broad readership. Complete data sets are presented electronically on the journal''s web site where appropriate. The journal also provides Reviews, Perspectives, and Insight/Outlook articles, which present commentary on the latest advances published both here and elsewhere, placing such progress in its broader biological context.