针对 SARS-CoV-2 的单克隆抗体疗法：前景与现实。

3区医学 Q2 Medicine Current topics in microbiology and immunology Pub Date : 2024-08-11 DOI:10.1007/82_2024_268

Daniele Focosi

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引用次数: 0

摘要

针对 SARS-CoV-2 Spike 蛋白的单克隆抗体已被广泛应用于正在进行的 COVID-19 大流行中。我在此回顾了这些疗法在早期大流行中的影响，从结构分类到临床试验结果，再到体外和体内基础免疫逃逸和治疗引起的免疫逃逸的证据。不幸的是，令人担忧的奥米克龙变体完全重置了迄今为止针对 COVID-19 的 mAb 疗法所取得的所有成就。尽管这种策略存在固有的局限性，但未来的发展，如通过呼吸道输送更多的工程化 mAb 鸡尾酒，可能会带来更好的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Monoclonal Antibody Therapies Against SARS-CoV-2: Promises and Realities.

Monoclonal antibodies targeting the Spike protein of SARS-CoV-2 have been widely deployed in the ongoing COVID-19 pandemic. I review here the impact of those therapeutics in the early pandemic, ranging from structural classification to outcomes in clinical trials to in vitro and in vivo evidence of basal and treatment-emergent immune escape. Unfortunately, the Omicron variant of concern has completely reset all achievements so far in mAb therapy for COVID-19. Despite the intrinsic limitations of this strategy, future developments such as respiratory delivery of further engineered mAb cocktails could lead to improved outcomes.

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来源期刊

Current topics in microbiology and immunology 医学-免疫学

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The review series Current Topics in Microbiology and Immunology provides a synthesis of the latest research findings in the areas of molecular immunology, bacteriology and virology. Each timely volume contains a wealth of information on the featured subject. This review series is designed to provide access to up-to-date, often previously unpublished information.