Juanhong Zhou, Xinyun Ma, Xiaofeng Liu, Yang Liu, Jiaojiao Fu, Yaling Qi, Huiling Liu
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Additionally, the review explores potential therapeutic strategies targeting histone lactylation.</p><p><strong>Methods: </strong>A comprehensive literature review was performed, analyzing recent findings on histone lactylation and its impact on cancer biology. This involved a systematic examination of studies focusing on biochemical pathways, cellular interactions, and clinical implications related to histone lactylation.</p><p><strong>Results: </strong>Histone lactylation was identified as a critical regulator of tumor cell DNA repair mechanisms and glycolytic metabolic abnormalities. It also significantly influences the functions of non-tumor cells within the TME, promoting tumor inflammatory responses and immune escape. Moreover, histone lactylation acts as a multifunctional biological signaling molecule impacting immune responses within the TME. Various cell types within the TME, including T cells and macrophages, were found to regulate tumor growth and immune escape mechanisms through lactylation.</p><p><strong>Conclusion: </strong>Histone lactylation offers a novel perspective on tumor metabolism and its role in cancer development. It presents promising opportunities for the development of innovative cancer therapies. 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引用次数: 0
摘要
背景：癌症的复杂性与其多方面的生物学过程密切相关，包括肿瘤微环境（TME）的作用以及遗传和代谢调控。组蛋白乳化是最近出现的一种新型表观遗传修饰机制，在调控癌症的发生、增殖、侵袭和转移方面发挥着关键作用：本综述旨在阐明组蛋白乳化在调节肿瘤生物学各方面的作用，包括DNA修复机制、糖代谢异常、非肿瘤细胞在肿瘤组织间质（TME）中的功能以及促进肿瘤炎症反应和免疫逃逸。此外，该综述还探讨了针对组蛋白乳化的潜在治疗策略：我们进行了全面的文献综述，分析了组蛋白乳化的最新发现及其对癌症生物学的影响。方法：我们对最近有关组蛋白乳化及其对癌症生物学影响的研究结果进行了全面的文献综述，其中包括对有关组蛋白乳化的生化途径、细胞相互作用和临床影响等方面的研究进行的系统检查：结果：组蛋白乳化被认为是肿瘤细胞 DNA 修复机制和糖代谢异常的关键调节因子。组蛋白乳化还能极大地影响TME内非肿瘤细胞的功能，促进肿瘤炎症反应和免疫逃逸。此外，组蛋白乳酰化还是一种多功能生物信号分子，可影响 TME 内的免疫反应。研究发现，TME 内的各种细胞类型，包括 T 细胞和巨噬细胞，都能通过乳化作用调节肿瘤生长和免疫逃逸机制：组蛋白乳化为肿瘤代谢及其在癌症发展中的作用提供了一个新的视角。它为开发创新型癌症疗法提供了大有可为的机会。这篇综述强调了组蛋白乳化作为治疗靶点的潜力，为癌症治疗的新策略铺平了道路。
The impact of histone lactylation on the tumor microenvironment and metabolic pathways and its potential in cancer therapy.
Background: The complexity of cancer is intricately linked to its multifaceted biological processes, including the roles of the tumor microenvironment (TME) as well as genetic and metabolic regulation. Histone lactylation has recently emerged as a novel epigenetic modification mechanism that plays a pivotal role in regulating cancer initiation, proliferation, invasion, and metastasis.
Objective: This review aims to elucidate the role of histone lactylation in modulating various aspects of tumor biology, including DNA repair mechanisms, glycolytic metabolic abnormalities, functions of non-tumor cells in the TME, and the promotion of tumor inflammatory responses and immune escape. Additionally, the review explores potential therapeutic strategies targeting histone lactylation.
Methods: A comprehensive literature review was performed, analyzing recent findings on histone lactylation and its impact on cancer biology. This involved a systematic examination of studies focusing on biochemical pathways, cellular interactions, and clinical implications related to histone lactylation.
Results: Histone lactylation was identified as a critical regulator of tumor cell DNA repair mechanisms and glycolytic metabolic abnormalities. It also significantly influences the functions of non-tumor cells within the TME, promoting tumor inflammatory responses and immune escape. Moreover, histone lactylation acts as a multifunctional biological signaling molecule impacting immune responses within the TME. Various cell types within the TME, including T cells and macrophages, were found to regulate tumor growth and immune escape mechanisms through lactylation.
Conclusion: Histone lactylation offers a novel perspective on tumor metabolism and its role in cancer development. It presents promising opportunities for the development of innovative cancer therapies. This review underscores the potential of histone lactylation as a therapeutic target, paving the way for new strategies in cancer treatment.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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