Asciminib：用于慢性髓性白血病一线治疗的新一代子弹。

IF 12.8 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Med Pub Date : 2024-08-09 DOI:10.1016/j.medj.2024.07.001

Chikashi Yoshida, Tomoiku Takaku

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引用次数: 0

摘要

慢性髓性白血病（CML）的标准治疗方法是使用酪氨酸激酶抑制剂（TKIs），抑制 BCR::ABL1 的酪氨酸激酶活性。Hochhaus等人报告说，在ASC4FIRST三期试验中，一种特异性靶向ABL肉豆蔻酰口袋的BCR::ABL1抑制剂Asciminib在新诊断的慢性期CML患者中显示出优于TKIs的疗效和良好的安全性。

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Asciminib: the next-generation bullet for first-line treatment of chronic myeloid leukemia.

The standard of care for chronic myeloid leukemia (CML) involves tyrosine kinase inhibitors (TKIs), which suppress tyrosine kinase activity of BCR::ABL1. Hochhaus et al. reported that asciminib, a BCR::ABL1 inhibitor specifically targeting the ABL myristoyl pocket, showed superior efficacy and favorable safety compared with TKIs in the phase 3 ASC4FIRST trial in patients with newly diagnosed chronic-phase CML.¹.

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来源期刊

Med MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

17.70

自引率

0.60%

发文量

102

期刊介绍： Med is a flagship medical journal published monthly by Cell Press, the global publisher of trusted and authoritative science journals including Cell, Cancer Cell, and Cell Reports Medicine. Our mission is to advance clinical research and practice by providing a communication forum for the publication of clinical trial results, innovative observations from longitudinal cohorts, and pioneering discoveries about disease mechanisms. The journal also encourages thought-leadership discussions among biomedical researchers, physicians, and other health scientists and stakeholders. Our goal is to improve health worldwide sustainably and ethically. Med publishes rigorously vetted original research and cutting-edge review and perspective articles on critical health issues globally and regionally. Our research section covers clinical case reports, first-in-human studies, large-scale clinical trials, population-based studies, as well as translational research work with the potential to change the course of medical research and improve clinical practice.