晚期 dMMR 结直肠癌中的 COX 抑制与抗 PD-1：改善抗原呈递？

IF 12.8 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Med Pub Date : 2024-08-09 DOI:10.1016/j.medj.2024.06.009

Benoit Rousseau, Paul Johannet

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引用次数: 0

摘要

dMMR 肿瘤具有较高的肿瘤突变和新抗原负担，对免疫检查点阻断具有较高的反应性。Wu 等人1 的研究表明，将 COX 抑制剂与 PD-1 阻断联合使用，是治疗 dMMR 转移性结直肠癌的一种安全有效的方法。该研究强调了这种联合疗法在实现对 dMMR 结直肠癌深度和持久反应方面的潜力。

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COX inhibition with anti-PD-1 in advanced dMMR colorectal cancer: Improving antigen presentation?

dMMR tumors, which have high tumor mutational and neoantigen burdens, are highly responsive to immune checkpoint blockade. Wu et al.¹ showed that combining COX inhibitors with PD-1 blockade could be a safe and effective treatment option for dMMR metastatic colorectal cancer. The study highlights the potential of this combination therapy in achieving deep and long-lasting responses in dMMR colorectal cancers.

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来源期刊

Med MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

17.70

自引率

0.60%

发文量

102

期刊介绍： Med is a flagship medical journal published monthly by Cell Press, the global publisher of trusted and authoritative science journals including Cell, Cancer Cell, and Cell Reports Medicine. Our mission is to advance clinical research and practice by providing a communication forum for the publication of clinical trial results, innovative observations from longitudinal cohorts, and pioneering discoveries about disease mechanisms. The journal also encourages thought-leadership discussions among biomedical researchers, physicians, and other health scientists and stakeholders. Our goal is to improve health worldwide sustainably and ethically. Med publishes rigorously vetted original research and cutting-edge review and perspective articles on critical health issues globally and regionally. Our research section covers clinical case reports, first-in-human studies, large-scale clinical trials, population-based studies, as well as translational research work with the potential to change the course of medical research and improve clinical practice.