针对体外皮肤模型的复杂性:前沿发展综述。

The Journal of investigative dermatology Pub Date : 2024-12-01 Epub Date: 2024-08-10 DOI:10.1016/j.jid.2024.04.032
Cristina Quílez, Luís B Bebiano, Eleri Jones, Uroš Maver, Luca Meesters, Piotr Parzymies, Emma Petiot, Gijs Rikken, Ignacio Risueño, Hamza Zaidi, Tanja Zidarič, Sander Bekeschus, Ellen H van den Bogaard, Matthew Caley, Helen Colley, Nuria Gago López, Sophia Letsiou, Christophe Marquette, Tina Maver, Rúben F Pereira, Desmond J Tobin, Diego Velasco
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引用次数: 0

摘要

皮肤体外模型在研究、测试药物、化妆品和医疗设备方面大有可为,可减少动物试验和大量临床试验。有几种体外方法可以模拟人类皮肤的行为,从简单的单层细胞到复杂的器官型和生物工程三维模型。其中一些已被批准用于化妆品、药品和化学品的临床前研究。然而,生理上可靠的体外人体皮肤模型的开发仍处于起步阶段。本综述报告了体外复杂皮肤模型在研究皮肤稳态、衰老和皮肤疾病方面的进展。
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Targeting the Complexity of In Vitro Skin Models: A Review of Cutting-Edge Developments.

Skin in vitro models offer much promise for research, testing drugs, cosmetics, and medical devices, reducing animal testing and extensive clinical trials. There are several in vitro approaches to mimicking human skin behavior, ranging from simple cell monolayer to complex organotypic and bioengineered 3-dimensional models. Some have been approved for preclinical studies in cosmetics, pharmaceuticals, and chemicals. However, development of physiologically reliable in vitro human skin models remains in its infancy. This review reports on advances in in vitro complex skin models to study skin homeostasis, aging, and skin disease.

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