基于代谢糖工程和二硫化硫的新型肿瘤治疗策略。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC Organic & Biomolecular Chemistry Pub Date : 2024-08-28 Epub Date: 2024-08-02 DOI:10.1039/d4ob01027b

Jie Li , Hao Chang , Pengzhe Zhang , Liyu Hou , Wei Li , Yixin Zhang , Zhiqi Lao

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引用次数: 0

摘要

传统的代谢糖工程涉及单功能非天然单糖的参与。为了拓宽这一强大技术的应用范围，本研究设计了一种双功能分子 Ac4ManNSSN3，并将其应用于肿瘤治疗策略。细胞和动物实验结果均显示了良好的原位肿瘤检测和抑瘤效果。

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A novel tumor theranostic strategy based on metabolic glycoengineering and disulfidptosis†‡

Traditional metabolic glycoengineering involves participation of a monofunctional unnatural monosaccharide. To broaden the application boundary of this powerful technique, a bifunctional molecule, Ac₄ManNSSN₃, is designed and applied for a tumor theranostic strategy in this work. The results from both cell and animal experiments show good in situ tumor detection and tumor inhibition effects.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.