揭开隐藏的联系:牙周病、核酸镰刀菌和癌症。

IF 4.7 2区 医学 Q1 ONCOLOGY Current Oncology Reports Pub Date : 2024-08-12 DOI:10.1007/s11912-024-01591-w
Elahe Akbari, Joel B Epstein, Firoozeh Samim
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引用次数: 0

摘要

综述目的:核滑杆菌(F. nucleatum)是一种厌氧革兰阴性微生物,常见于人类牙科生物膜和肠道菌群。长期以来,人们一直知道它在牙周病中浓度较高,最近又被认为与口腔癌和远处癌症(如结直肠癌、胃肠癌、食管癌、乳腺癌、胰腺癌、肝癌和泌尿生殖系统癌症)有关。然而,人们对其参与癌症发展的机制尚未进行充分讨论。本综述旨在介绍核酸酵母菌与癌症在生物学分子和临床方面的关系:研究表明,F. nucleatum 通过慢性炎症、免疫逃避、细胞增殖激活和直接细胞相互作用促进肿瘤发生,如在口腔鳞状细胞癌(OSCC)中。在结直肠癌(CRC)中,F. nucleatum通过β-catenin信号传导和NF-κB激活促进肿瘤发生。它还能诱导自噬,导致 CRC 和食管癌的化疗耐药性,并通过减少 T 细胞浸润促进乳腺癌的肿瘤生长和转移。F. nucleatum 与癌变和 OSCC 中细菌多样性的增加有关,改善口腔卫生有可能预防 OSCC。F. nucleatum 通过细胞因子和活性氧引起突变和表观遗传变化,从而诱发癌症。它还会促进 CRC 的化疗抗药性。通过非侵入性检测方法,核酸酵母菌有可能成为各种癌症的诊断工具。要发现它在诊断和治疗 OSCC 及其他癌症方面的潜力,还需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Unveiling the Hidden Links: Periodontal Disease, Fusobacterium Nucleatum, and Cancers.

Purpose of review: Fusobacterium nucleatum (F. nucleatum), an anaerobic, gram-negative microbe, commonly found in human dental biofilm and the gut flora. It has long been known to have a higher concentration in periodontal disease and has recently been implicated in both oral and distant cancers such as colorectal, gastrointestinal, esophageal, breast, pancreatic hepatocellular, and genitourinary cancers. However, the mechanism of its involvement in the development of cancer has not been fully discussed. This review aims to cover biological molecular and clinical aspects of F. nucleatum and cancers.

Recent findings: Studies indicate F. nucleatum promotes tumor development through chronic inflammation, immune evasion, cell proliferation activation, and direct cell interactions, as in oral squamous cell carcinoma (OSCC). In colorectal cancer (CRC), F. nucleatum contributes to tumorigenesis through β-catenin signaling and NF-κB activation. It also induces autophagy, leading to chemoresistance in CRC and esophageal cancers, and enhances tumor growth and metastasis in breast cancer by reducing T-cell infiltration. F. nucleatum is linked to carcinogenesis and increased bacterial diversity in OSCC, with improved oral hygiene potentially preventing OSCC. F. nucleatum triggers cancer by causing mutations and epigenetic changes through cytokines and reactive oxygen species. It also promotes chemoresistance in CRC. F. nucleatum may potentially serve as a diagnostic tool in various cancers, with non-invasive detection methods available. Further investigation is needed to discover its potential in the diagnosis and treatment of OSCC and other cancers.

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来源期刊
CiteScore
8.50
自引率
0.00%
发文量
187
审稿时长
6-12 weeks
期刊介绍: This journal aims to review the most important, recently published clinical findings in the field of oncology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those affected by cancer. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as cancer prevention, leukemia, melanoma, neuro-oncology, and palliative medicine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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