早期经济活动损失对治愈治疗后胃癌幸存者全因死亡率的影响:韩国一项全国性研究。

IF 6 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Gastric Cancer Pub Date : 2024-11-01 Epub Date: 2024-08-12 DOI:10.1007/s10120-024-01541-2
Byungyoon Yun, Juyeon Oh, Heejoo Park, Jinsoo Chung, Juho Sim, Jongmin Lee, Yangwook Kim, Jin-Ha Yoon
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引用次数: 0

摘要

背景:经济活动对癌症幸存者健康的影响值得关注。我们的研究旨在探讨胃癌幸存者早期丧失经济活动(EA)与全因死亡风险之间的关系:这项回顾性队列研究利用了韩国国民健康保险服务机构的数据,研究对象为 2009 年 1 月至 2013 年 12 月期间接受手术或内镜治疗的 30-59 岁胃癌患者。主要结果指标为全因死亡率。当患者的保险状态在治疗后一年内转变为依赖型时,即确定为早期丧失EA。使用多变量考克斯比例危险模型估算了全因死亡率的调整危险比(HRs)和95%置信区间(CI),并对手术组和内镜组进行了单独分析:在 24159 名患者(中位随访时间为 9.9 年)中,有 2976 人(12.3%)全因死亡。其中,2835 例死亡发生在手术组患者身上,141 例死亡发生在内窥镜手术组患者身上。在手术组和内窥镜手术组中,分别有14.4%和7.7%的患者早期丧失EA。手术组与 EA 早期丧失相关的全因死亡率调整 HRs(95% CI)为 1.39(1.27-1.54),内窥镜手术组为 2.27(1.46-3.52):本研究强调了胃癌根治术后早期EA丧失与全因死亡风险增加之间的重要关联。它强调了维持 EA 在提高这些幸存者健康状况方面的关键作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Impact of early economic activity loss on all-cause mortality in gastric cancer survivors following curative treatment: a nationwide study in Korea.

Background: The impact of economic engagement on the health of cancer survivors is notable. Our study aims to explore the association between early loss of economic activity (EA) and the risk of all-cause mortality among gastric cancer survivors.

Methods: This retrospective cohort study utilized data from Korea's National Health Insurance Service, focusing on 30-59-year-old gastric cancer patients who received either surgery or endoscopic procedures from January 2009 to December 2013. The primary outcome measure was all-cause mortality. Early loss of EA was identified when a patient's insurance status shifted to dependent within one year following treatment. Adjusted hazard ratios (HRs) and 95% confidence intervals (CI) for all-cause mortality were estimated using multivariable Cox proportional hazards models, conducting separate analyses for surgical and endoscopic groups.

Results: Among 24,159 patients (median follow-up, 9.9 years), 2976 (12.3%) experienced all-cause mortality. Specifically, 2835 of these deaths occurred in patients who underwent surgery, while 141 were in the endoscopic procedure group. Early loss of EA was recorded in 14.4% of the surgery group and 7.7% of the endoscopic procedure group. Adjusted HRs (95% CI) for all-cause mortality associated with early loss of EA were 1.39 (1.27-1.54) for the surgery group and 2.27 (1.46-3.52) for the endoscopic procedure group.

Conclusions: This study highlights a significant association between the early loss of EA and an increased risk of all-cause mortality in those who have undergone curative treatments for gastric cancer. It underscores the crucial role of sustaining EA in enhancing the health outcomes of these survivors.

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来源期刊
Gastric Cancer
Gastric Cancer 医学-胃肠肝病学
CiteScore
14.70
自引率
2.70%
发文量
80
审稿时长
6-12 weeks
期刊介绍: Gastric Cancer is an esteemed global forum that focuses on various aspects of gastric cancer research, treatment, and biology worldwide. The journal promotes a diverse range of content, including original articles, case reports, short communications, and technical notes. It also welcomes Letters to the Editor discussing published articles or sharing viewpoints on gastric cancer topics. Review articles are predominantly sought after by the Editor, ensuring comprehensive coverage of the field. With a dedicated and knowledgeable editorial team, the journal is committed to providing exceptional support and ensuring high levels of author satisfaction. In fact, over 90% of published authors have expressed their intent to publish again in our esteemed journal.
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