ANDROID 和 A/G 比率与 2 型糖尿病患者的肌肉疏松症有关。

IF 3.9 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Therapeutic Advances in Endocrinology and Metabolism Pub Date : 2024-08-07 eCollection Date: 2024-01-01 DOI:10.1177/20420188241269181
Dongxiao Zhang, Chen Li, Wenchao Hu, Lanjie He
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引用次数: 0

摘要

背景:脂肪分布在糖耐量受损中起着重要作用。安卓脂肪症(ANDROID)和妇科脂肪症(GYNOID)已被证实与胰岛素抵抗有关。较高的肌肉疏松症风险与 2 型糖尿病(T2DM)有关。本研究评估了 T2DM 患者的 ANDROID、GYNOID 以及 ANDROID 与 GYNOID 比率(A/G 比率),以确定它们是否与肌肉疏松症相关:我们招募了1086名T2DM患者,测量了骨骼肌指数(SMI)、ANDROID、GYNOID,并收集了临床数据:结果:119 名男性 T2DM 患者患有肌肉疏松症(20.24%),72 名女性患者患有肌肉疏松症(16.51%)。所有 ANDROID 和 A/G 比率较高的 T2DM 患者患肌肉疏松症的风险均有所降低。在患有 T2DM 的受试者中,SMI 与 ANDROID 和 A/G 比率存在相关性:结论:ANDROID 和 A/G 比率与 T2DM 患者的肌少症成反比。
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ANDROID and A/G ratio are correlated with sarcopenia among type 2 diabetes patients.

Background: Fat distribution plays an important role in impaired glucose tolerance. Android adiposity (ANDROID) and gynoid adiposity (GYNOID) have been proven to be linked with insulin resistance. A higher risk of sarcopenia is associated with type 2 diabetes mellitus (T2DM). In this study, ANDROID, GYNOID, and ANDROID to GYNOID ratios (A/G ratios) were evaluated in T2DM patients to determine if they were associated with sarcopenia.

Methods: We recruited 1086 T2DM patients, measured skeletal muscle index (SMI), ANDROID, GYNOID, and collected clinical data.

Results: T2DM patients with 119 male subjects had sarcopenia (20.24%), and 72 female subjects had sarcopenia (16.51%). All patients with T2DM who had high ANDROID and A/G ratios were at a reduced risk of sarcopenia. The SMI showed a correlation with ANDROID and A/G ratios among subjects with T2DM.

Conclusion: ANDROID and A/G ratios are inversely related to sarcopenia in T2DM patients.

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来源期刊
Therapeutic Advances in Endocrinology and Metabolism
Therapeutic Advances in Endocrinology and Metabolism Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
7.70
自引率
2.60%
发文量
42
审稿时长
8 weeks
期刊介绍: Therapeutic Advances in Endocrinology and Metabolism delivers the highest quality peer-reviewed articles, reviews, and scholarly comment on pioneering efforts and innovative studies across all areas of endocrinology and metabolism.
期刊最新文献
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