一个潜在的前景:胸腔内生理盐水灌注配合胸腔内泰乐菌素治疗胸腔积液的新疗法。

IF 0.8 Q4 RESPIRATORY SYSTEM Respirology Case Reports Pub Date : 2024-08-10 eCollection Date: 2024-08-01 DOI:10.1002/rcr2.70000
Mas Fazlin Mohamad Jailaini, Noor Amirah Saini, Mohd Jazman Che Rahim, Mohamed Faisal Abdul Hamid
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引用次数: 0

摘要

多年来,胸腔积液的治疗方法不断发展,包括使用胸膜腔内纤维蛋白溶解疗法(IPFT),例如阿替普酶和胸膜腔内脱氧核糖核酸酶(DNase),以加强胸腔积液的引流。在此,我们报告了两例胸腔积液病例,除使用肠外抗生素作为治疗支柱外,还采用了胸腔内生理盐水灌注和胸腔内泰乐菌素治疗。两例患者均避免了外科手术(去骨瓣),并顺利出院。经随访,两例患者均显示临床治愈、生化恢复和放射学改善,表明治疗效果良好。这是首次报道将生理盐水冲洗与泰乐菌素联合作为胸膜感染替代疗法的病例。
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A potential prospect: The novel treatment of intrapleural saline irrigation with intrapleural tyloxapol in treating thoracic empyema.

The treatment for empyema thoracis has been evolving over the years, including the usage of intrapleural fibrinolytic therapy (IPFT), for example, alteplase with intrapleural deoxyribonuclease (DNase) to enhance the drainage of pleural effusion. Here, we report two cases of thoracic empyema that were successfully treated with intrapleural saline irrigation and intrapleural tyloxapol apart from parenteral antibiotics as the pillar of the treatment. Both patients averted surgical procedure (decortication) and were discharged well. Upon follow-up, both cases showed clinical cure, biochemical recovery, and radiological improvement, indicating a good treatment outcome. This is the first reported cases on combination of saline irrigation with tyloxapol as alternative treatment for pleural infection.

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来源期刊
Respirology Case Reports
Respirology Case Reports RESPIRATORY SYSTEM-
CiteScore
1.40
自引率
0.00%
发文量
178
审稿时长
8 weeks
期刊介绍: Respirology Case Reports is an open-access online journal dedicated to the publication of original clinical case reports, case series, clinical images and clinical videos in all fields of respiratory medicine. The Journal encourages the international exchange between clinicians and researchers of experiences in diagnosing and treating uncommon diseases or diseases with unusual presentations. All manuscripts are peer-reviewed through a streamlined process that aims at providing a rapid turnaround time from submission to publication.
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