提高肾移植疗效:尿液蛋白质组学在监测移植物功能和检测排斥反应中的作用。

IF 3.8 3区 生物学 Q1 BIOCHEMICAL RESEARCH METHODS Expert Review of Proteomics Pub Date : 2024-07-01 Epub Date: 2024-08-12 DOI:10.1080/14789450.2024.2389829
Merita Rroji, Andreja Figurek, Goce Spasovski
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引用次数: 0

摘要

导言:肾移植大大改善了终末期肾病患者的生活,为透析提供了最佳替代方案。然而,针对新器官的复杂免疫反应导致的急性和慢性排斥机制威胁着移植的成功:正在进行的生物标志物研究有望彻底改变移植健康的早期检测和监测。液体活检技术提供了一条新途径,几种诊断性、预测性和预后性生物标志物有望检测和监测肾脏疾病以及早期和慢性移植物排斥反应:专家观点:评估与肾移植结果相关的蛋白质组成,可以确定生物标志物,从而深入了解移植物的功能。非侵入性蛋白质组生物标志物如果能成功实现这一转变,就能大大提高临床效果,并改变患者和医生评估肾移植的方式。因此,蛋白质组技术的进步将大大提高人们对与肾移植结果相关的蛋白质标志物和分子机制的认识。然而,从发现到在临床实践中使用这些蛋白质的道路是漫长的,需要不断的验证,需要超越单一的研究团队,需要全面的基础设施和跨研究小组的合作。
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Advancing kidney transplant outcomes: the role of urinary proteomics in graft function monitoring and rejection detection.

Introduction: Kidney transplantation significantly improves the lives of those with end-stage kidney disease, offering best alternative to dialysis. However, transplant success is threatened by the acute and chronic rejection mechanisms due to complex immune responses against the new organ.

Areas covered: The ongoing research into biomarkers holds promise for revolutionizing the early detection and monitoring of the graft health. Liquid biopsy techniques offer a new avenue, with several diagnostic, predictive, and prognostic biomarkers showing promise in detecting and monitoring kidney diseases and an early and chronic allograft rejection.

Expert opinion: Evaluating the protein composition related to kidney transplant results could lead to identifying biomarkers that provide insights into the graft functionality. Non-invasive proteomic biomarkers can drastically enhance clinical outcomes and change the way how kidney transplants are evaluated for patients and physicians if they succeed in this transition. Hence, the advancement in proteomic technologies, leads toward a significant improvement in understanding of the protein markers and molecular mechanisms linked to the outcomes of kidney transplants. However, the road from discovery to the use of such proteins in clinical practice is long, with a need for continuous validation and beyond the singular research team with comprehensive infrastructure and across research groups collaboration.

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来源期刊
Expert Review of Proteomics
Expert Review of Proteomics 生物-生化研究方法
CiteScore
7.60
自引率
0.00%
发文量
20
审稿时长
6-12 weeks
期刊介绍: Expert Review of Proteomics (ISSN 1478-9450) seeks to collect together technologies, methods and discoveries from the field of proteomics to advance scientific understanding of the many varied roles protein expression plays in human health and disease. The journal coverage includes, but is not limited to, overviews of specific technological advances in the development of protein arrays, interaction maps, data archives and biological assays, performance of new technologies and prospects for future drug discovery. The journal adopts the unique Expert Review article format, offering a complete overview of current thinking in a key technology area, research or clinical practice, augmented by the following sections: Expert Opinion - a personal view on the most effective or promising strategies and a clear perspective of future prospects within a realistic timescale Article highlights - an executive summary cutting to the author''s most critical points.
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