{"title":"利用花芯光子晶体光纤架构的便携式生物传感器加强乳腺癌生物标记物检测","authors":"Devika veluchamy, Murugan Senthil Mani Rajan, Yogendra Kumar Prajapati","doi":"10.1007/s11468-024-02470-7","DOIUrl":null,"url":null,"abstract":"<p>This study introduces a biosensor utilizing photonic crystal fiber (PCF) technology to detect breast cancer biomarkers. The biosensor features a unique flower core composed of square and circular air holes. The sensing mechanism relies on variations in the resonant wavelength induced by changes in the sample’s concentration or refractive index. As the sample’s concentration increases, the transmission spectrum shifts at higher wavelengths, enabling differentiation between malignant and normal cancer cells. The study demonstrates that the biosensor has achieved its highest recorded sensitivity of 22,069 nm/RIU. Furthermore, comprehensive values to judge the performance are obtained for loss, coupling length, V parameter, propagation constant, amplitude sensitivity, and transmission, in addition to birefringence on the order of 10<sup>−5</sup>. Thus, the reported biosensor is of high quality and has good potential for sensitive detection of breast cancer. Also, the biosensor presented in this study provides a viable and cost-efficient alternative to molecular biotechnology examination and imaging techniques for the diagnosis of cancer.</p>","PeriodicalId":736,"journal":{"name":"Plasmonics","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Enhancing Breast Cancer Biomarker Detection with a Portable Biosensor Utilizing Flower Core Photonic Crystal Fiber Architecture\",\"authors\":\"Devika veluchamy, Murugan Senthil Mani Rajan, Yogendra Kumar Prajapati\",\"doi\":\"10.1007/s11468-024-02470-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>This study introduces a biosensor utilizing photonic crystal fiber (PCF) technology to detect breast cancer biomarkers. The biosensor features a unique flower core composed of square and circular air holes. The sensing mechanism relies on variations in the resonant wavelength induced by changes in the sample’s concentration or refractive index. As the sample’s concentration increases, the transmission spectrum shifts at higher wavelengths, enabling differentiation between malignant and normal cancer cells. The study demonstrates that the biosensor has achieved its highest recorded sensitivity of 22,069 nm/RIU. Furthermore, comprehensive values to judge the performance are obtained for loss, coupling length, V parameter, propagation constant, amplitude sensitivity, and transmission, in addition to birefringence on the order of 10<sup>−5</sup>. Thus, the reported biosensor is of high quality and has good potential for sensitive detection of breast cancer. Also, the biosensor presented in this study provides a viable and cost-efficient alternative to molecular biotechnology examination and imaging techniques for the diagnosis of cancer.</p>\",\"PeriodicalId\":736,\"journal\":{\"name\":\"Plasmonics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-08-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Plasmonics\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://doi.org/10.1007/s11468-024-02470-7\",\"RegionNum\":4,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Plasmonics","FirstCategoryId":"101","ListUrlMain":"https://doi.org/10.1007/s11468-024-02470-7","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Enhancing Breast Cancer Biomarker Detection with a Portable Biosensor Utilizing Flower Core Photonic Crystal Fiber Architecture
This study introduces a biosensor utilizing photonic crystal fiber (PCF) technology to detect breast cancer biomarkers. The biosensor features a unique flower core composed of square and circular air holes. The sensing mechanism relies on variations in the resonant wavelength induced by changes in the sample’s concentration or refractive index. As the sample’s concentration increases, the transmission spectrum shifts at higher wavelengths, enabling differentiation between malignant and normal cancer cells. The study demonstrates that the biosensor has achieved its highest recorded sensitivity of 22,069 nm/RIU. Furthermore, comprehensive values to judge the performance are obtained for loss, coupling length, V parameter, propagation constant, amplitude sensitivity, and transmission, in addition to birefringence on the order of 10−5. Thus, the reported biosensor is of high quality and has good potential for sensitive detection of breast cancer. Also, the biosensor presented in this study provides a viable and cost-efficient alternative to molecular biotechnology examination and imaging techniques for the diagnosis of cancer.
期刊介绍:
Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons.
Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.