利用花芯光子晶体光纤架构的便携式生物传感器加强乳腺癌生物标记物检测

IF 3.3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL Plasmonics Pub Date : 2024-08-07 DOI:10.1007/s11468-024-02470-7
Devika veluchamy, Murugan Senthil Mani Rajan, Yogendra Kumar Prajapati
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引用次数: 0

摘要

本研究介绍了一种利用光子晶体光纤(PCF)技术检测乳腺癌生物标志物的生物传感器。该生物传感器具有一个由方形和圆形气孔组成的独特花芯。其传感机制依赖于样品浓度或折射率变化引起的谐振波长变化。随着样品浓度的增加,透射光谱会向高波长移动,从而区分恶性和正常癌细胞。研究表明,该生物传感器的灵敏度达到了 22069 nm/RIU 的最高记录。此外,还获得了损耗、耦合长度、V 参数、传播常量、振幅灵敏度和透射率的综合值,以及 10-5 数量级的双折射,以判断其性能。因此,报告的生物传感器质量很高,具有灵敏检测乳腺癌的良好潜力。此外,本研究中提出的生物传感器为诊断癌症提供了一种可行的、具有成本效益的分子生物技术检查和成像技术替代方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Enhancing Breast Cancer Biomarker Detection with a Portable Biosensor Utilizing Flower Core Photonic Crystal Fiber Architecture

This study introduces a biosensor utilizing photonic crystal fiber (PCF) technology to detect breast cancer biomarkers. The biosensor features a unique flower core composed of square and circular air holes. The sensing mechanism relies on variations in the resonant wavelength induced by changes in the sample’s concentration or refractive index. As the sample’s concentration increases, the transmission spectrum shifts at higher wavelengths, enabling differentiation between malignant and normal cancer cells. The study demonstrates that the biosensor has achieved its highest recorded sensitivity of 22,069 nm/RIU. Furthermore, comprehensive values to judge the performance are obtained for loss, coupling length, V parameter, propagation constant, amplitude sensitivity, and transmission, in addition to birefringence on the order of 10−5. Thus, the reported biosensor is of high quality and has good potential for sensitive detection of breast cancer. Also, the biosensor presented in this study provides a viable and cost-efficient alternative to molecular biotechnology examination and imaging techniques for the diagnosis of cancer.

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来源期刊
Plasmonics
Plasmonics 工程技术-材料科学:综合
CiteScore
5.90
自引率
6.70%
发文量
164
审稿时长
2.1 months
期刊介绍: Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons. Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.
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