{"title":"利用手性亚磺酰胺试剂不对称构建 C[sbnd]N、C[sbnd]O 和 C[sbnd]S 键的最新进展","authors":"","doi":"10.1016/j.tetlet.2024.155243","DOIUrl":null,"url":null,"abstract":"<div><p>Chiral sulfinamides have emerged as versatile tools in various asymmetric reactions, especially in the generation of chiral amines through asymmetric C<img>C bond formation reactions involving chiral sulfinyl imines derived from sulfinamides and aldehyde or ketones. The prospect of employing sulfinamide auxiliaries in stereoselective carbon–heteroatom bond formation reactions has received considerable attention. This review examines recent advancements in stereoselective reactions involving chiral sulfinamide reagents, focusing on C<img>N, C<img>O, and C<img>S bond formation reactions. The article elucidates the mechanisms and stereocontrol aspects underlying these asymmetric reactions, highlighting their utility in the synthesis of bioactive compounds.</p></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Recent progress in the asymmetric construction of CN, CO, and CS bonds using chiral sulfinamide reagents\",\"authors\":\"\",\"doi\":\"10.1016/j.tetlet.2024.155243\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Chiral sulfinamides have emerged as versatile tools in various asymmetric reactions, especially in the generation of chiral amines through asymmetric C<img>C bond formation reactions involving chiral sulfinyl imines derived from sulfinamides and aldehyde or ketones. The prospect of employing sulfinamide auxiliaries in stereoselective carbon–heteroatom bond formation reactions has received considerable attention. This review examines recent advancements in stereoselective reactions involving chiral sulfinamide reagents, focusing on C<img>N, C<img>O, and C<img>S bond formation reactions. The article elucidates the mechanisms and stereocontrol aspects underlying these asymmetric reactions, highlighting their utility in the synthesis of bioactive compounds.</p></div>\",\"PeriodicalId\":438,\"journal\":{\"name\":\"Tetrahedron Letters\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2024-08-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tetrahedron Letters\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0040403924003381\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron Letters","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040403924003381","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
摘要
手性亚磺酰胺已成为各种不对称反应中的多用途工具,特别是通过涉及由亚磺酰胺和醛或酮衍生的手性亚磺酰亚胺的不对称 CC 键形成反应生成手性胺。在立体选择性碳-异原子键形成反应中使用亚磺酰胺助剂的前景受到了广泛关注。本综述探讨了涉及手性亚磺酰胺试剂的立体选择性反应的最新进展,重点关注 CN、CO 和 CS 键形成反应。文章阐明了这些不对称反应的机理和立体控制方面的问题,强调了它们在合成生物活性化合物中的作用。
Recent progress in the asymmetric construction of CN, CO, and CS bonds using chiral sulfinamide reagents
Chiral sulfinamides have emerged as versatile tools in various asymmetric reactions, especially in the generation of chiral amines through asymmetric CC bond formation reactions involving chiral sulfinyl imines derived from sulfinamides and aldehyde or ketones. The prospect of employing sulfinamide auxiliaries in stereoselective carbon–heteroatom bond formation reactions has received considerable attention. This review examines recent advancements in stereoselective reactions involving chiral sulfinamide reagents, focusing on CN, CO, and CS bond formation reactions. The article elucidates the mechanisms and stereocontrol aspects underlying these asymmetric reactions, highlighting their utility in the synthesis of bioactive compounds.
期刊介绍:
Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.