Rui-An Wang , Li-Zheng Ren , Shi-Qing Han , Bang-Guo Wei
{"title":"通过 BF3-Et2O 介导的 N-Boc 苯磺酰基与亚酰胺的方法，一步合成 3,4-二氢-[1,3]恶嗪-2-酮","authors":"Rui-An Wang , Li-Zheng Ren , Shi-Qing Han , Bang-Guo Wei","doi":"10.1016/j.tetlet.2024.155222","DOIUrl":null,"url":null,"abstract":"<div><p>An efficient one-pot approach to access functionalized 3,4-dihydro-[1,3]oxazin-2-one skeletons has been developed through BF<sub>3</sub>·Et<sub>2</sub>O-mediated addition-cyclization of ynamides and <em>N-</em>Boc phenylsulfones. The metal-free catalytic method exhibits good functional group compatibility. This study provides a practical new method for the synthesis of oxazinone skeletons.</p></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"147 ","pages":"Article 155222"},"PeriodicalIF":1.5000,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"One-pot synthesis of 3,4-dihydro-[1,3]oxazin-2-ones by BF3·Et2O-mediated approach of N-Boc phenylsulfonyl with ynamides\",\"authors\":\"Rui-An Wang , Li-Zheng Ren , Shi-Qing Han , Bang-Guo Wei\",\"doi\":\"10.1016/j.tetlet.2024.155222\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>An efficient one-pot approach to access functionalized 3,4-dihydro-[1,3]oxazin-2-one skeletons has been developed through BF<sub>3</sub>·Et<sub>2</sub>O-mediated addition-cyclization of ynamides and <em>N-</em>Boc phenylsulfones. The metal-free catalytic method exhibits good functional group compatibility. This study provides a practical new method for the synthesis of oxazinone skeletons.</p></div>\",\"PeriodicalId\":438,\"journal\":{\"name\":\"Tetrahedron Letters\",\"volume\":\"147 \",\"pages\":\"Article 155222\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2024-08-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tetrahedron Letters\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0040403924003174\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron Letters","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040403924003174","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
One-pot synthesis of 3,4-dihydro-[1,3]oxazin-2-ones by BF3·Et2O-mediated approach of N-Boc phenylsulfonyl with ynamides
An efficient one-pot approach to access functionalized 3,4-dihydro-[1,3]oxazin-2-one skeletons has been developed through BF3·Et2O-mediated addition-cyclization of ynamides and N-Boc phenylsulfones. The metal-free catalytic method exhibits good functional group compatibility. This study provides a practical new method for the synthesis of oxazinone skeletons.
期刊介绍：
Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.
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