现代欧洲人新石器时代引入的与 IL23R 相关的保护功能可预防慢性炎症性肠病

bioRxiv - Evolutionary Biology Pub Date : 2024-08-07 DOI:10.1101/2024.08.06.606840

Ben Krause-Kyora, Nicolas Antonio da Silva, Elif Kaplan, Daniel Kolbe, Archaeological Civilization Disease Consortium (ACDC), Inken Wohlers, Hauke Busch, David Ellinghaus, Amke Caliebe, Efe Sezgin, Almut Nebel, Stefan Schreiber

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摘要

背景 IL23R 基因中的低位变异 rs11209026-A 在欧洲人中对免疫相关疾病，尤其是炎症性肠病 (IBD) 有显著的保护作用。目前，A 基因等位基因在欧洲的平均出现率为 5%。

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Neolithic introgression of IL23R-related protection against chronic inflammatory bowel diseases in modern Europeans

Background The hypomorphic variant rs11209026-A in the IL23R gene provides significant protection against immune-related diseases in Europeans, notably inflammatory bowel disease (IBD). Today, the A-allele occurs with an average frequency of 5% in Europe.

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bioRxiv - Evolutionary Biology

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