亚洲年轻男性心肺功能的纵向变化及其与心血管疾病和全因死亡率的关系:一项队列研究

IF 3.9 Q1 SPORT SCIENCES BMJ Open Sport & Exercise Medicine Pub Date : 2024-08-01 DOI:10.1136/bmjsem-2024-001986
Alexander Wilhelm Gorny, Suriya Prakaash, Jia Wei Neo, Weien Chow, Khung Keong Yeo, Jonathan Yap, Falk Müller-Riemenschneider
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引用次数: 0

摘要

引言 青壮年时期的心肺功能(CRF)是慢性疾病风险的一个决定因素。为了更好地了解心肺功能是否也可以作为一种可调节的风险因素,我们研究了健康年轻男性队列中 2.4 公里跑步时间的纵向变化与健康结果之间的关系。方法 我们的数据集包括个人跑步时间和四个国家登记册中记录的健康结果。我们使用 Cox 比例危险模型来研究基线跑步时间与首次主要不良心血管事件 (MACE) 和全因死亡率 (ACM) 的相对危险度之间的关系。使用根据基线跑步时间进行调整的模型估算了与跑步时间纵向变化相关的相对危险度。结果 研究样本包括 148 825 名 18-34 岁的健康男性,他们至少接受过两次间隔 5-9 年的常规体能测试。在 1 294 778 人年的随访中,我们观察到 1275 例首次 MACE 和 764 例 ACM 事件,平均年龄分别为 43.2 岁(SD 6.0)和 39.2 岁(SD 6.6)。每年跑步时间每增加 1%,首次发生 MACE 的风险就增加 1.13 倍(95% CI 1.10 至 1.16),发生 ACM 的风险增加 1.06 倍(95% CI 1.02 至 1.10)。在使用基线体重指数调整模型进行的敏感性分析中,跑步时间的纵向变化与首次 MACE 之间的关系保持不变。结论 在 35 岁以下的男性中,跑步时间的纵向变化与 20 年后罹患心血管疾病的风险有关。数据可能来自第三方,不对外公开。本研究中的数据来自国家登记处和新加坡武装部队,只有在获得上述机构批准后方可提供。
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Longitudinal change in cardiorespiratory fitness and the association with cardiovascular disease and all-cause mortality in young Asian men: a cohort study
Introduction Cardiorespiratory fitness (CRF) in young adulthood is a determinant of chronic disease risk. To better understand whether CRF might also behave as a modifiable risk factor, we examined the associations between longitudinal changes in 2.4 km run times and health outcomes in a cohort of healthy young men. Methods Our dataset comprised individual run times and health outcomes captured in four national registries. Cox proportional hazards models were used to examine the association between baseline run times and relative hazards of first major adverse cardiovascular events (MACE) and all-cause mortality (ACM). Relative hazards associated with longitudinal change in run times were estimated using models that were adjusted for run-time at baseline. Results The study sample comprised 148 825 healthy men ages 18–34 years who had undergone at least two routine fitness tests that were 5–9 years apart. During 1 294 778 person-years of follow-up, we observed 1275 first MACE and 764 ACM events occurring at mean ages of 43.2 (SD 6.0) years and 39.2 (SD 6.6) years, respectively. A 1% increase in run-time per annum was associated with a 1.13 (95% CI 1.10 to 1.16) times greater hazard of first MACE and a 1.06 (95% CI 1.02 to 1.10) times greater hazard of ACM. The association between longitudinal change in run times and first MACE was preserved in sensitivity analyses using models adjusted for body mass index at baseline. Conclusion Among men under the age of 35 years, longitudinal change in run times was associated with the risk of cardiovascular disease two decades onwards. Data may be obtained from a third party and are not publicly available. The data in this study have been obtained from national registries and the Singapore Armed Forces and can only be made available with the approval of the aforementioned.
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CiteScore
7.10
自引率
4.20%
发文量
106
审稿时长
20 weeks
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