利用量子点生物传感器组件动态监测生物分子随时间变化的情况

Biosensors Pub Date : 2024-08-07 DOI:10.3390/bios14080380
Razvan Bocu
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引用次数: 0

摘要

对作为细胞膜一部分的生物大分子进行动态监测通常是一项挑战。电化学发光(ECL)生物传感器组件在显微成像方面具有明显优势。因此,本文提出并分析了一种基于量子点的生物传感器组件。因此,本文特别关注作为细胞膜一部分的生物分子。此外,本文还描述并分析了一种基于量子点的生物传感器组件,该组件用于实现一个全功能的彩色 ECL 可视化系统,该系统可准确地观察细胞和生物分子结构。相关的纳米发射器可以实现实时生物成像。因此,针对生物分子随时间变化的演变情况,对所提出的方法进行了全面评估。结果表明,传统上存在问题的结构,如作为细胞膜一部分的生物分子,都可以利用所提出的解决方案来研究和监测其随时间变化的动态演化。所报告的研究过程是在与一家专业生物医学工程公司合作的情况下进行的,所描述的结果有望为更好地理解生物分子随时间变化的动态演化提供实质性支持。
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Dynamic Monitoring of Time-Dependent Evolution of Biomolecules Using Quantum Dots-Based Biosensors Assemblies
The dynamic monitoring of biomolecules that are part of cell membranes generally constitutes a challenge. Electrochemiluminescence (ECL) biosensor assemblies provide clear advantages concerning microscopic imaging. Therefore, this paper proposes and analyzes a quantum dots-based biosensor assembly. Thus, particular attention is granted to biomolecules that are part of cell membranes. Additionally, this paper describes and analyzes a quantum dots-based biosensor assembly, which is used to implement a fully functional color ECL visualization system that allows for cellular and biomolecular structures to be accurately visualized. The related nano-emitter allows the implementation of real-time bioimaging scenarios. Consequently, the proposed approach is thoroughly evaluated relative to the time-dependent evolution of biomolecules. It has been demonstrated that traditionally problematic structures, like the biomolecules that are part of cell membranes, can be studied and monitored relative to their time-dependent dynamic evolution using the proposed solution. The reported research process has been conducted in the realm of cooperation with a specialized biomedical engineering company, and the described results are expected to substantially support a better understanding of the biomolecules’ time-dependent dynamic evolution.
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