果蝇锌指蛋白 CG9609 与 SAGA 复合体的去泛素化 (DUB) 模块相互作用并参与转录调控

IF 1.5 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular Biology Pub Date : 2024-08-07 DOI:10.1134/s0026893324700274

J. V. Nikolenko, M. M. Kurshakova, D. V. Kopytova, Y. A. Vdovina, N. E. Vorobyova, A. N. Krasnov

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引用次数: 0

摘要

摘要在之前的研究中，我们发现锌指蛋白Su(Hw)和CG9890与果蝇SAGA复合体相互作用，参与活性染色质结构的形成和转录调控。在这项研究中，我们发现了 SAGA 复合物的 DUB 模块与另一种锌指蛋白 CG9609 的相互作用。我们进行了 ChIP-Seq 分析，确定了 CG9609 在果蝇基因组中的结合位点。对结合位点的分析表明，它们主要定位于基因启动子。研究表明，CG9609 蛋白参与了基因表达的调控。

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The Drosophila Zinc Finger Protein CG9609 Interacts with the Deubiquitinating (DUB) Module of the SAGA Complex and Participates in the Regulation of Transcription

Abstract

In previous studies, we found that the zinc finger proteins Su(Hw) and CG9890 interact with the Drosophila SAGA complex and participate in the formation of the active chromatin structure and transcription regulation. In this research, we discovered the interaction of the DUB module of the SAGA complex with another zinc finger protein, CG9609. ChIP-Seq analysis was performed, and CG9609 binding sites in the Drosophila genome were identified. Analysis of binding sites showed that they are localized predominantly at gene promoters. The CG9609 protein has been shown to be involved in the regulation of gene expression.

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来源期刊

Molecular Biology 生物-生化与分子生物学

CiteScore

1.30

自引率

8.30%

发文量

审稿时长

3 months

期刊介绍： Molecular Biology is an international peer reviewed journal that covers a wide scope of problems in molecular, cell and computational biology including genomics, proteomics, bioinformatics, molecular virology and immunology, molecular development biology, molecular evolution and related areals. Molecular Biology publishes reviews, experimental and theoretical works. Every year, the journal publishes special issues devoted to most rapidly developing branches of physical-chemical biology and to the most outstanding scientists.