细胞外基质中手指驱动细胞扩散的变分模型

IF 1.9 3区工程技术 Q3 MECHANICS Meccanica Pub Date : 2024-08-07 DOI:10.1007/s11012-024-01835-w

Antonino Favata, Andrea Rodella, Stefano Vidoli

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引用次数: 0

摘要

我们为纤维材料提出了一个简单的化学机械变分模型，该模型描述了：（i）由于微观屈曲不稳定性而出现的各向异性；（ii）在新创建的宏观带的驱动下，以强烈压缩变形为特征的细胞相在基底中的扩散。该模型适用于模拟细胞在组织内的扩散及其在间充质迁移过程中与组织重塑的相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A variational model for finger-driven cell diffusion in the extracellular matrix

We present a simple chemo-mechanical variational model for a fibrous material that describes (i) the emergence of the anisotropy due to microscopic buckling instabilities (ii) a diffusion in the substrate of the cell phase driven by the new created macroscopic bands characterized by intense compressive deformation. The model is applicable for simulating the spreading of cells within tissues and their interaction with tissue remodeling during mesenchymal migration.

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来源期刊

Meccanica 物理-力学

CiteScore

4.70

自引率

3.70%

发文量

151

审稿时长

7 months

期刊介绍： Meccanica focuses on the methodological framework shared by mechanical scientists when addressing theoretical or applied problems. Original papers address various aspects of mechanical and mathematical modeling, of solution, as well as of analysis of system behavior. The journal explores fundamental and applications issues in established areas of mechanics research as well as in emerging fields; contemporary research on general mechanics, solid and structural mechanics, fluid mechanics, and mechanics of machines; interdisciplinary fields between mechanics and other mathematical and engineering sciences; interaction of mechanics with dynamical systems, advanced materials, control and computation; electromechanics; biomechanics. Articles include full length papers; topical overviews; brief notes; discussions and comments on published papers; book reviews; and an international calendar of conferences. Meccanica, the official journal of the Italian Association of Theoretical and Applied Mechanics, was established in 1966.