成熟 B 细胞和 T 细胞淋巴瘤分类中的肿瘤基因组学：我们现在在哪里？

Diagnostic Histopathology Pub Date : 2024-08-01 DOI:10.1016/j.mpdhp.2024.05.005

Satyen Gohil, Sabine Pomplun

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引用次数: 0

摘要

大规模测序研究彻底改变了我们对淋巴瘤分子畸变的认识，确定了基因突变、转录状态和表观遗传失调，从而定义了具有不同生物学特性和结果的关键亚型。在此，我们将以成熟的 B 细胞和 T 细胞肿瘤为重点，介绍这些发现，并讨论它们在这一广阔而快速发展的领域中的意义。

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Oncogenomics in the classification of mature B-and T-cell lymphomas: where are we now?

Our understanding of the molecular aberrations in lymphoma, has been revolutionized by large scale sequencing studies, which has identified genetic mutations, transcriptional states and epigenetic dysregulation that define key subtypes with distinct biological properties and outcomes. Herein we provide an introduction to these findings, with a focus on mature B and T cell neoplasms, and discuss their significance in this vast and immensely fast moving field.

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来源期刊

Diagnostic Histopathology Medicine-Pathology and Forensic Medicine

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： This monthly review journal aims to provide the practising diagnostic pathologist and trainee pathologist with up-to-date reviews on histopathology and cytology and related technical advances. Each issue contains invited articles on a variety of topics from experts in the field and includes a mini-symposium exploring one subject in greater depth. Articles consist of system-based, disease-based reviews and advances in technology. They update the readers on day-to-day diagnostic work and keep them informed of important new developments. An additional feature is the short section devoted to hypotheses; these have been refereed. There is also a correspondence section.

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