COVID-19 对小儿哮喘影响的最新见解。

IF 3.9 3区 医学 Q2 IMMUNOLOGY Expert Review of Clinical Immunology Pub Date : 2024-08-27 DOI:10.1080/1744666X.2024.2390641
Carolina da Silva Alves, Raquel Baptista Pestana, Mário Morais-Almeida
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引用次数: 0

摘要

导言:严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)的出现以及随后的冠状病毒病 2019(COVID-19)大流行引发了有关其对小儿哮喘影响的问题。本综述分析了最新研究,以全面了解 COVID-19 与小儿哮喘之间的动态关系:这篇叙述性综述研究了 COVID-19 对小儿哮喘的影响,探讨了临床结果、免疫反应、推荐治疗方法、SARS-CoV-2 株系的影响以及 COVID-19 疫苗接种。数据来源于2020年1月至2023年11月的数据库(PubMed、Embase和BioRxiv/MedRxiv):为应对 COVID-19 大流行,国际科学界迅速发展了广泛的知识,展现了前所未有的合作。尽管取得了这些进展,但有关 SARS-CoV-2 感染和小儿哮喘的问题依然存在。大多数研究都是流行病学研究,研究方法各不相同,有时会得出相互矛盾的结果。虽然哮喘一般不会增加儿童患严重 COVID-19 的风险,但不受控制的哮喘是一个风险因素,这突出了保持哮喘控制的重要性。远程医疗已被证明对哮喘控制有效,尽管有其局限性,但仍将继续发展。值得注意的是,过敏性哮喘可能对严重的 COVID-19 有保护作用。我们建议包括哮喘患者在内的儿童群体接种 COVID-19 疫苗。
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Recent insights into the impacts of COVID-19 on pediatric asthma.

Introduction: The emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the subsequent coronavirus disease 2019 (COVID-19) pandemic has raised questions about its impact on pediatric asthma. This review analyzes the latest research to offer a comprehensive understanding of the dynamics between COVID-19 and pediatric asthma.

Areas covered: This narrative review examines the effects of COVID-19 on pediatric asthma, exploring clinical outcomes, immune responses, recommended treatments, the impact of SARS-CoV-2 strains, and COVID-19 vaccination. Data were sourced from databases (PubMed, Embase, and BioRxiv/MedRxiv) from January 2020 to November 2023.

Expert opinion: In response to the COVID-19 pandemic, the international scientific community rapidly developed extensive knowledge, demonstrating unprecedented cooperation. Despite these advances, questions remain about SARS-CoV-2 infection and pediatric asthma. Most research consists of epidemiological studies with varying methods, sometimes yielding contradictory results. While asthma generally did not increase the risk of severe COVID-19 in children, uncontrolled asthma was a risk factor, highlighting the importance of maintaining asthma management. Telemedicine has proven effective for asthma control and will continue to grow, despite its limitations. Notably, allergic asthma may have a protective role against severe COVID-19. We recommend COVID-19 vaccination in the pediatric age group, including those with asthma.

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来源期刊
CiteScore
7.60
自引率
2.30%
发文量
221
审稿时长
6-12 weeks
期刊介绍: Expert Review of Clinical Immunology (ISSN 1744-666X) provides expert analysis and commentary regarding the performance of new therapeutic and diagnostic modalities in clinical immunology. Members of the International Editorial Advisory Panel of Expert Review of Clinical Immunology are the forefront of their area of expertise. This panel works with our dedicated editorial team to identify the most important and topical review themes and the corresponding expert(s) most appropriate to provide commentary and analysis. All articles are subject to rigorous peer-review, and the finished reviews provide an essential contribution to decision-making in clinical immunology. Articles focus on the following key areas: • Therapeutic overviews of specific immunologic disorders highlighting optimal therapy and prospects for new medicines • Performance and benefits of newly approved therapeutic agents • New diagnostic approaches • Screening and patient stratification • Pharmacoeconomic studies • New therapeutic indications for existing therapies • Adverse effects, occurrence and reduction • Prospects for medicines in late-stage trials approaching regulatory approval • Novel treatment strategies • Epidemiological studies • Commentary and comparison of treatment guidelines Topics include infection and immunity, inflammation, host defense mechanisms, congenital and acquired immunodeficiencies, anaphylaxis and allergy, systemic immune diseases, organ-specific inflammatory diseases, transplantation immunology, endocrinology and diabetes, cancer immunology, neuroimmunology and hematological diseases.
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