The Usefulness of Low-Kiloelectron Volt Virtual Monochromatic Contrast-Enhanced Computed Tomography with Deep Learning Image Reconstruction Technique in Improving the Delineation of Pancreatic Ductal Adenocarcinoma.

To evaluate the usefulness of low-keV multiphasic computed tomography (CT) with deep learning image reconstruction (DLIR) in improving the delineation of pancreatic ductal adenocarcinoma (PDAC) compared to conventional hybrid iterative reconstruction (HIR). Thirty-five patients with PDAC who underwent multiphasic CT were retrospectively evaluated. Raw data were reconstructed with two energy levels (40 keV and 70 keV) of virtual monochromatic imaging (VMI) using HIR (ASiR-V50%) and DLIR (TrueFidelity-H). Contrast-to-noise ratio (CNR_tumor) was calculated from the CT values within regions of interest in tumor and normal pancreas in the pancreatic parenchymal phase images. Lesion conspicuity of PDAC in pancreatic parenchymal phase on 40-keV HIR, 40-keV DLIR, and 70-keV DLIR images was qualitatively rated on a 5-point scale, using 70-keV HIR images as reference (score 1 = poor; score 3 = equivalent to reference; score 5 = excellent) by two radiologists. CNR_tumor of 40-keV DLIR images (median 10.4, interquartile range (IQR) 7.8-14.9) was significantly higher than that of the other VMIs (40 keV HIR, median 6.2, IQR 4.4-8.5, P < 0.0001; 70-keV DLIR, median 6.3, IQR 5.1-9.9, P = 0.0002; 70-keV HIR, median 4.2, IQR 3.1-6.1, P < 0.0001). CNR_tumor of 40-keV DLIR images were significantly better than those of the 40-keV HIR and 70-keV HIR images by 72 ± 22% and 211 ± 340%, respectively. Lesion conspicuity scores on 40-keV DLIR images (observer 1, 4.5 ± 0.7; observer 2, 3.4 ± 0.5) were significantly higher than on 40-keV HIR (observer 1, 3.3 ± 0.9, P < 0.0001; observer 2, 3.1 ± 0.4, P = 0.013). DLIR is a promising reconstruction method to improve PDAC delineation in 40-keV VMI at the pancreatic parenchymal phase compared to conventional HIR.