评估美国队列中的慢性胰腺炎预后评分。

IF 3 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Clinical and Translational Gastroenterology Pub Date : 2024-08-13 DOI:10.14309/ctg.0000000000000758
Soo Kyung Park, Darwin L Conwell, Phil A Hart, Shuang Li, Kimberly Stello, Evan L Fogel, William E Fisher, Christopher E Forsmark, Stephen J Pandol, Walter G Park, Mark Topazian, Jose Serrano, Santhi Swaroop Vege, Stephen K Van Den Eeden, Liang Li, Dhiraj Yadav, Jami L Saloman
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引用次数: 0

摘要

简介慢性胰腺炎预后评分(COPPS)旨在区分疾病严重程度并预测未来住院风险。在这项队列研究中,我们评估了 COPPS 是否能预测美国队列中住院的可能性:CPDPC联盟提供了慢性胰腺炎受试者的数据和血清(N=279)。根据基线数据计算 COPPS,并按严重程度(低、中、高)进行分层。主要终点包括12个月随访期间的住院次数和住院时间:结果:COPPS的平均值(含)为8.4±1.6。COPPS与所有主要结局相关:任何原因住院(次数:r=0.15,p=0.01;持续时间:r=0.16,p=0.01)和胰腺相关住院(次数:r=0.15,p=0.02;持续时间:r=0.13,p=0.04)。严重程度分布为低度 13.3%、中度 66.0%、高度 20.8%。37.6%的受试者因任何原因住院≥1次;32.2%的受试者因胰腺相关原因住院≥1次。所有主要结果在严重程度组之间均有明显差异:任何原因住院(次数,P=0.004;持续时间,P=0.007)和胰腺相关住院(次数,P=0.02;持续时间,P=0.04)。低度组和中度组在随访时继续饮酒的比例更高(p=0.04)。入组时(p=0.02)和随访时(p=0.04)的焦虑发生率较高:从统计学角度看,COPPS与住院结果有明显的相关性,但相关性比以往的研究要弱,这可能与PROCEED队列的门诊性质和高严重程度疾病的发病率较低有关。要了解 COPPS 作为临床风险评估和干预潜在工具的全部效用,还需要对其他前瞻性队列进行研究。
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Evaluation of Chronic Pancreatitis Prognosis Score in an American Cohort.

Introduction: Chronic Pancreatitis Prognosis Score (COPPS) was developed to discriminate disease severity and predict risk for future hospitalizations. In this cohort study, we evaluated if COPPS predicts the likelihood of hospitalization(s) in an American cohort.

Methods: The Chronic Pancreatitis, Diabetes, and Pancreatic Cancer consortium provided data and serum from subjects with chronic pancreatitis (N = 279). COPPS was calculated with baseline data and stratified by severity (low, moderate, and high). Primary endpoints included number and duration of hospitalizations during 12-month follow-up.

Results: The mean ± SD COPPS was 8.4 ± 1.6. COPPS correlated with all primary outcomes: hospitalizations for any reason (number: r = 0.15, P = 0.01; duration: r = 0.16, P = 0.01) and pancreas-related hospitalizations (number: r = 0.15, P = 0.02; duration: r = 0.13, P = 0.04). The severity distribution was 13.3% low, 66.0% moderate, and 20.8% high. 37.6% of subjects had ≥1 hospitalization(s) for any reason; 32.2% had ≥1 pancreas-related hospitalizations. All primary outcomes were significantly different between severity groups: hospitalizations for any reason (number, P = 0.004; duration, P = 0.007) and pancreas-related hospitalizations (number, P = 0.02; duration, P = 0.04). The prevalence of continued drinking at follow-up ( P = 0.04) was higher in the low and moderate groups. The prevalence of anxiety at enrollment ( P = 0.02) and follow-up ( P < 0.05) was higher in the moderate and high groups.

Discussion: Statistically, COPPS significantly correlated with hospitalization outcomes, but the correlations were weaker than in previous studies, which may be related to the outpatient nature of the PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies cohort and lower prevalence of high severity disease. Studies in other prospective cohorts are needed to understand the full utility of COPPS as a potential tool for clinical risk assessment and intervention.

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来源期刊
Clinical and Translational Gastroenterology
Clinical and Translational Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
7.00
自引率
0.00%
发文量
114
审稿时长
16 weeks
期刊介绍: Clinical and Translational Gastroenterology (CTG), published on behalf of the American College of Gastroenterology (ACG), is a peer-reviewed open access online journal dedicated to innovative clinical work in the field of gastroenterology and hepatology. CTG hopes to fulfill an unmet need for clinicians and scientists by welcoming novel cohort studies, early-phase clinical trials, qualitative and quantitative epidemiologic research, hypothesis-generating research, studies of novel mechanisms and methodologies including public health interventions, and integration of approaches across organs and disciplines. CTG also welcomes hypothesis-generating small studies, methods papers, and translational research with clear applications to human physiology or disease. Colon and small bowel Endoscopy and novel diagnostics Esophagus Functional GI disorders Immunology of the GI tract Microbiology of the GI tract Inflammatory bowel disease Pancreas and biliary tract Liver Pathology Pediatrics Preventative medicine Nutrition/obesity Stomach.
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