Zdeněk Kejík, Jan Hajduch, Nikita Abramenko, Frédéric Vellieux, Kateřina Veselá, Jindřiška Leischner Fialová, Kateřina Petrláková, Kateřina Kučnirová, Robert Kaplánek, Ameneh Tatar, Markéta Skaličková, Michal Masařík, Petr Babula, Petr Dytrych, David Hoskovec, Pavel Martásek, Milan Jakubek
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引用次数: 0
摘要
线粒体失调在致癌过程中起着重要作用。另一方面，线粒体的不稳定性会严重抑制癌细胞的生存能力和转移潜力。光动力疗法和光热疗法（PDT 和 PTT）可有效靶向线粒体，提供创新的非侵入性抗癌治疗模式。具有线粒体强选择性的氰基染料在增强 PDT 和 PTT 方面显示出巨大的潜力。本文讨论了氰基染料在线粒体透射光治疗和线粒体穿刺治疗中的潜力和局限性，以及它们在联合疗法、治疗技术和最佳给药系统中的应用。此外，还介绍了使用光活性氰基染料进行声动力疗法的新方法，突显了癌症治疗的进展。
Cyanine dyes in the mitochondria-targeting photodynamic and photothermal therapy
Mitochondrial dysregulation plays a significant role in the carcinogenesis. On the other hand, its destabilization strongly represses the viability and metastatic potential of cancer cells. Photodynamic and photothermal therapies (PDT and PTT) target mitochondria effectively, providing innovative and non-invasive anticancer therapeutic modalities. Cyanine dyes, with strong mitochondrial selectivity, show significant potential in enhancing PDT and PTT. The potential and limitations of cyanine dyes for mitochondrial PDT and PTT are discussed, along with their applications in combination therapies, theranostic techniques, and optimal delivery systems. Additionally, novel approaches for sonodynamic therapy using photoactive cyanine dyes are presented, highlighting advances in cancer treatment. Photodynamic and photothermal therapies (PDT and PTT) target mitochondria effectively, providing innovative and non-invasive anticancer therapeutic modalities. Here, the authors summarize the promise and limitations of cyanine dyes in enhancing mitochondrial PDT and PTT in cancer treatment.
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Communications Chemistry is an open access journal from Nature Research publishing high-quality research, reviews and commentary in all areas of the chemical sciences. Research papers published by the journal represent significant advances bringing new chemical insight to a specialized area of research. We also aim to provide a community forum for issues of importance to all chemists, regardless of sub-discipline.
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