交联透明质酸皮肤填充剂用于矫正 III 和 IV 型皮肤中度至重度鼻唇沟的安全性和有效性评估

IF 3.7 4区 医学 Q1 DERMATOLOGY Dermatologic Therapy Pub Date : 2024-08-14 DOI:10.1155/2024/8487221
Taraneh Yazdanparast, Saman Ahmad Nasrollahi, Aniseh Samadi, Hamidreza Kafi, Mansour Nassiri Kashani, Azin Ayatollahi, Alireza Firooz
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引用次数: 0

摘要

简介玻尿酸填充剂被广泛用于矫正鼻唇沟。这种治疗方法具有良好的美学效果。本研究的目的是对 Lunaphil Ultra 皮下填充剂在伊朗菲茨帕特里克皮肤 III 型和 IV 型人群中用于矫正鼻唇沟的安全性和有效性进行评估。研究方法在这项前后对比的临床研究中,24 名女性和 6 名男性志愿者(平均年龄:43.36 岁,标准差:11.55 岁)的鼻唇沟中注射了 Lunaphil Ultra 皮肤填充剂。两名独立医生根据 Allergan 量表,分别在注射前、2 周、12 周和 24 周后对鼻唇沟的严重程度进行了评估。此外,还测量了两侧鼻唇沟的体积、深度和面积,以及右侧鼻唇沟真皮层的厚度和密度。此外,还记录了不良反应和受试者的满意度。结果在第 2 周、第 12 周和第 24 周,分别有 81%、57% 和 65% 的受试者的鼻唇沟得到了一级或一级以上的改善。在所有随访中,Allergan量表的中位数得分均显著下降。在所有随访中,鼻唇沟面积的中位值都明显减少。注射两周后,真皮密度明显增加。注射时疼痛程度的平均值为 1.96(满分 10 分)。不良反应轻微且短暂。不同随访的满意度中位数为 9-10 分(满分 10 分)。结论研究结果表明,含有利多卡因的交联透明质酸皮肤填充剂可用于临床实践,以矫正 III 型和 IV 型皮肤的鼻唇沟,安全性和有效性都很高。未来更全面的研究将证实这些结果。本试验已注册为 IRCT20150101020514N11。
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Safety and Efficacy Assessment of a Cross-linked Hyaluronic Acid Dermal Filler for Correction of Moderate-to-Severe Nasolabial Folds in Skin Types III and IV

Introduction. Hyaluronic acid fillers are widely used to correct nasolabial folds. This treatment provides favorable aesthetic outcomes. The aim of this study was the safety and efficacy evaluation of Lunaphil Ultra intradermal filler for correcting nasolabial folds in the Iranian population with Fitzpatrick skin types III and IV. Methods. In this before and after clinical study, Lunaphil Ultra dermal filler was injected in nasolabial folds of 24 female and 6 male volunteers (mean age: 43.36 and SD: 11.55). Two independent physicians assessed the severity of nasolabial folds before injection and 2, 12, and 24 weeks later, according to the Allergan scale. The volume, depth, and area of both nasolabial folds and the thickness and density of the dermis in the right nasolabial fold were also measured. Adverse events and subject satisfaction were also recorded. Results. One grade or more improvement was detected in 81%, 57%, and 65% of participants at weeks 2, 12, and 24, respectively. The median score for the Allergan scale decreased significantly in all follow-up visits. The median value of the area of nasolabial folds significantly reduced in all follow-up visits. Two weeks after injection, dermis density showed a significant increase. The mean score for pain level during the injection was 1.96 out of 10. Adverse events were mild and transient. The median satisfaction scores were 9-10 out of 10 at different visits. Conclusion. The findings showed that cross-linked hyaluronic acid dermal filler containing lidocaine could be applied in clinical practice for correction of nasolabial folds in skin types III and IV, with high safety and efficacy. More comprehensive future research could approve these results. This trial is registered with IRCT20150101020514N11.

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来源期刊
Dermatologic Therapy
Dermatologic Therapy 医学-皮肤病学
CiteScore
7.00
自引率
8.30%
发文量
711
审稿时长
3 months
期刊介绍: Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.
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