脊柱手术中的阿片类药物替代品。

IF 2.3 3区 医学 Q2 ANESTHESIOLOGY Current Opinion in Anesthesiology Pub Date : 2024-10-01 Epub Date: 2024-08-06 DOI:10.1097/ACO.0000000000001423
Shobana Rajan, Gaiha Rishi, Marco Ibrahim
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引用次数: 0

摘要

审查目的:不断升级的阿片类药物危机加剧了为脊柱手术患者探索其他疼痛治疗策略的必要性。这篇综述综述了围手术期阿片类药物替代治疗的最新研究,评估了其疗效、副作用和术后效果,因此非常及时且具有现实意义:最近的研究结果:我们进行了一次系统性检索,以获取过去 18 个月内研究阿片类药物替代策略的文章。研究结果表明,结合非甾体类抗炎药(NSAIDs)、对乙酰氨基酚、利多卡因、加巴喷丁类、N-甲基-D-天冬氨酸(NMDA)拮抗剂、右美托咪定以及新出现的区域阻滞技术(如竖脊肌阻滞和TLIF(胸腰椎筋膜间阻滞))的多模式镇痛可以在不影响疼痛缓解的情况下显著减少阿片类药物的用量。此外,这些方法还能减少与阿片类药物相关的副作用,如术后恶心、呕吐和住院时间延长等。摘要:多模式镇痛的使用符合当前的疼痛管理指南,并能解决与阿片类药物滥用相关的公共卫生问题。这些替代方法虽然有效,但并非没有副作用,最终结果取决于效益与风险之间的平衡。未来的研究应重点关注阿片类药物替代品的长期疗效、在不同人群中的有效性,以及这些策略的进一步验证和优化。
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Opioid alternatives in spine surgeries.

Purpose of review: The escalating opioid crisis has intensified the need to explore alternative pain management strategies for patients undergoing spine surgery. This review is timely and relevant as it synthesizes recent research on opioid alternatives for perioperative management, assessing their efficacy, side effects, and postoperative outcomes.

Recent findings: A systematic search was conducted to capture articles from the past 18 months that examined opioid-sparing strategies. Findings indicate that multimodal analgesia, incorporating nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, lidocaine, gabapentinoids, N-methyl-D-aspartate (NMDA) antagonists, dexmedetomidine, and emerging regional block techniques like the erector spinae block and TLIF (thoraco lumbar interfascial block), can significantly reduce opioid consumption without compromising pain relief. Additionally, these approaches reduce opioid-related side effects such as postoperative nausea, vomiting, and prolonged hospital stays.

Summary: The use of multimodal analgesia aligns with current pain management guidelines and addresses public health concerns related to opioid misuse. While effective, these alternatives are not without side effects, and the ultimate outcome depends on balancing benefits and risks. Future research should focus on the long-term outcomes of opioid alternatives, their effectiveness across diverse populations, and further validation and optimization of these strategies.

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来源期刊
CiteScore
4.90
自引率
8.00%
发文量
207
审稿时长
12 months
期刊介绍: ​​​​​​​​Published bimonthly and offering a unique and wide ranging perspective on the key developments in the field, each issue of Current Opinion in Anesthesiology features hand-picked review articles from our team of expert editors. With fifteen disciplines published across the year – including cardiovascular anesthesiology, neuroanesthesia and pain medicine – every issue also contains annotated references detailing the merits of the most important papers.
期刊最新文献
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