PRAME 免疫组化技术在检测细微黑色素瘤微卫星中的应用。

IF 1.1 4区医学 Q4 DERMATOLOGY American Journal of Dermatopathology Pub Date : 2024-10-01 Epub Date: 2024-08-14 DOI:10.1097/DAD.0000000000002817

Maged Daruish, Sanwadana Karunaratne, Paula Duffy-Gadd, Samantha Hansford, Saleem Taibjee

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引用次数: 0

摘要

摘要：微卫星沉积是恶性黑色素瘤的一个预后因素。它的确定会导致随后的分期升高，并对进一步的治疗产生影响。我们描述了 6 个病例，在这些病例中，黑色素瘤中干扰素表达抗原的免疫组化染色有助于在扫描放大镜下发现小的微转移灶，而常规切片可能会漏掉这些微转移灶。

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Utility of PRAME Immunohistochemistry in the Detection of Subtle Melanoma Microsatellites.

Abstract: Microsatellitosis is well established as a prognostic factor in malignant melanoma. Its identification leads to subsequent upstaging with implications for further management. We describe 6 cases in which immunohistochemical staining for PReferentially expressed Antigen in MElanoma facilitated detection of small foci of micrometastasis on scanning magnification, which may be potentially missed in routine sections.

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来源期刊

American Journal of Dermatopathology 医学-皮肤病学

CiteScore

1.80

自引率

9.10%

发文量

453

审稿时长

3 months

期刊介绍： The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports. With the The American Journal of Dermatopathology you''ll be able to: -Incorporate step-by-step coverage of new or difficult-to-diagnose conditions from their earliest histopathologic signs to confirmatory immunohistochemical and molecular studies. -Apply the latest basic science findings and clinical approaches to your work right away. -Tap into the skills and expertise of your peers and colleagues the world over peer-reviewed original articles, "Extraordinary cases reports", coverage of practical guidelines, and graphic presentations. -Expand your horizons through the Journal''s idea-generating forum for debating controversial issues and learning from preeminent researchers and clinicians

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