M Ozcan, W Teughels, B Alkaya, O U Turer, F Selimli, H G Kayhan, H S Yıldız, M C Haytac
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引用次数: 0
摘要
这项动物研究的目的是比较在植入骨之前浸泡在Limosilactobacillus reuteri、胆钙化醇-D3（维生素 D）和可注射富血小板纤维蛋白（i-PRF）悬浮液/溶液中的植入体的主要/次要稳定性以及显微 CT 骨和组织体积。将 40 个种植体（每组 10 个）植入 5 只绵羊的髂嵴。植入前将植入物浸泡在 L. reuteri、维生素 D 或 i-PRF 溶液中五分钟，或不浸泡作为对照组。植入物的稳定性由 ISQ 值决定，植入物周围的骨量则由显微 CT 评估进行组织形态分析。4 周后，L. reuteri 组的种植体显示出最高的次生稳定性以及 2- 和 3D BV/TV 值。与 i-PRF 组和对照组的植入物相比，L. reuteri 和维生素 D 浸泡植入物的骨结合值更高。盐酸克仑特罗和维生素 D 浸泡植入物之间没有统计学差异。在研究范围内，研究结果表明，在将种植体植入骨内之前，将种植体浸泡在L. reuteri或维生素D悬浮液/溶液中可能会对骨结合产生有益的影响。
Effects of dental implant surface biomodification with Limosilactobacillus reuteri on early bone healing: an experimental animal study.
The aim of this animal study was to compare the primary/secondary stability and micro-CT bone and tissue volumes of implants that were immersed in Limosilactobacillus reuteri, cholecalciferol-D3 (vitamin D) and injectable platelet-rich fibrin (i-PRF) suspensions/solutions before placement in bone. 40 implants (10 in each group) were placed in the iliac crest of 5 sheep. The implants were immersed in L. reuteri, vitamin D or i-PRF solutions for five minutes before placement or left unsoaked as controls. Implant stability was determined by ISQ values and bone volume around implants was histomorphometrically analysed by micro-CT evaluation. At 4 weeks, implants in the L. reuteri group showed the highest secondary stability and 2- and 3D BV/TV values. Both L. reuteri and vitamin D immersed implants had higher osseointegration values compared to the implants in the i-PRF group and controls. There were no statistical differences between L. reuteri and vitamin D immersed implants. Within the limits of the study, the results suggest that immersing implants in L. reuteri or vitamin D suspensions/solutions before implant placement in bone may have beneficial effects on osseointegration.
期刊介绍：
Beneficial Microbes is a peer-reviewed scientific journal with a specific area of focus: the promotion of the science of microbes beneficial to the health and wellbeing of man and animal. The journal contains original research papers and critical reviews in all areas dealing with beneficial microbes in both the small and large intestine, together with opinions, a calendar of forthcoming beneficial microbes-related events and book reviews. The journal takes a multidisciplinary approach and focuses on a broad spectrum of issues, including safety aspects of pro- & prebiotics, regulatory aspects, mechanisms of action, health benefits for the host, optimal production processes, screening methods, (meta)genomics, proteomics and metabolomics, host and bacterial physiology, application, and role in health and disease in man and animal. Beneficial Microbes is intended to serve the needs of researchers and professionals from the scientific community and industry, as well as those of policy makers and regulators.
The journal will have five major sections:
* Food, nutrition and health
* Animal nutrition
* Processing and application
* Regulatory & safety aspects
* Medical & health applications
In these sections, topics dealt with by Beneficial Microbes include:
* Worldwide safety and regulatory issues
* Human and animal nutrition and health effects
* Latest discoveries in mechanistic studies and screening methods to unravel mode of action
* Host physiology related to allergy, inflammation, obesity, etc.
* Trends in application of (meta)genomics, proteomics and metabolomics
* New developments in how processing optimizes pro- & prebiotics for application
* Bacterial physiology related to health benefits
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