下一代肺替代疗法的前景:通过囊胚补体生成功能性全肺。

IF 1.8 4区 医学 Q3 TRANSPLANTATION Current Opinion in Organ Transplantation Pub Date : 2024-10-01 Epub Date: 2024-07-30 DOI:10.1097/MOT.0000000000001169
Dai Shimizu, Akihiro Miura, Munemasa Mori
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引用次数: 0

摘要

综述目的:囊胚补体是下一代肺替代疗法中前景广阔的前沿领域。本综述旨在阐明肺囊胚补体在临床环境中的未来前景,总结通过该技术生成功能性肺的最新研究。它还探讨和讨论了与种间嵌合体形成相关的宿主动物选择,这是通过囊胚补体产生功能性人肺时不可或缺的一项挑战:最近的研究结果:利用各种基因突变来创建空置的肺龛,从而提高供体细胞对啮齿动物模型互补肺的贡献效率。通过控制细胞系诱导基因突变,肺上皮细胞和间质细胞的嵌合能力都得到了提高。种间囊胚互补凸显了物种间发育程序的复杂性,已发现多个基因可增强人类与其他哺乳动物之间嵌合体的形成。摘要:虽然功能性肺已通过种内囊胚互补产生,但功能性种间肺的产生仍未实现。解决控制宿主肺生态位和选择与供体人类和宿主细胞间种间障碍相关的宿主动物的难题,对于在大型动物中生成功能性人化肺或整个人类肺至关重要。
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The perspective for next-generation lung replacement therapies: functional whole lung generation by blastocyst complementation.

Purpose of review: Blastocyst complementation represents a promising frontier in next-generation lung replacement therapies. This review aims to elucidate the future prospects of lung blastocyst complementation within clinical settings, summarizing the latest studies on generating functional lungs through this technique. It also explores and discusses host animal selection relevant to interspecific chimera formation, a challenge integral to creating functional human lungs via blastocyst complementation.

Recent findings: Various gene mutations have been utilized to create vacant lung niches, enhancing the efficacy of donor cell contribution to the complemented lungs in rodent models. By controlling the lineage to induce gene mutations, chimerism in both the lung epithelium and mesenchyme has been improved. Interspecific blastocyst complementation underscores the complexity of developmental programs across species, with several genes identified that enhance chimera formation between humans and other mammals.

Summary: While functional lungs have been generated via intraspecies blastocyst complementation, the generation of functional interspecific lungs remains unrealized. Addressing the challenges of controlling the host lung niche and selecting host animals relevant to interspecific barriers between donor human and host cells is critical to enabling the generation of functional humanized or entire human lungs in large animals.

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来源期刊
CiteScore
4.10
自引率
4.50%
发文量
124
审稿时长
6-12 weeks
期刊介绍: ​​​​​​Current Opinion in Organ Transplantation is an indispensable resource featuring key, up-to-date and important advances in the field from around the world. Led by renowned guest editors for each section, every bimonthly issue of Current Opinion in Organ Transplantation delivers a fresh insight into topics such as stem cell transplantation, immunosuppression, tolerance induction and organ preservation and procurement. With 18 sections in total, the journal provides a convenient and thorough review of the field and will be of interest to researchers, surgeons and other healthcare professionals alike.
期刊最新文献
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