泛免疫炎症值作为儿童红斑狼疮预后预测指标的实用性。

IF 1.9 4区 医学 Q3 RHEUMATOLOGY Lupus Pub Date : 2024-10-01 Epub Date: 2024-08-16 DOI:10.1177/09612033241275227
Ali Alasmari, Haifa Aldakhil, Abdulaziz Almutairi, Mohammed Nashawi, Emtenan Basahl, Awatif Abushhaiwia, Soad Hashad, Hala Etayari, Yusra Elfawires, Khulood Walid Khawaja, Reima Bakry, Lujayn Akbar, Edward De Vol, Alhanouf AlSaleem, Sulaiman M Al-Mayouf
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引用次数: 0

摘要

背景:系统性红斑狼疮(SLE)是一种慢性多系统炎症性疾病。在整个病程中监测疾病的活动性对于有效管理和评估疾病的预后非常重要:目的:评估诊断时的泛免疫炎症值(PIIV)能否预测儿童系统性红斑狼疮(cSLE)患者发病 12 个月后的器官受累情况和疾病活动性:这是一项观察性回顾多中心研究,研究对象是2010年1月至2022年12月期间在参与研究的中心就诊并接受随访的儿童系统性红斑狼疮患者。所有患者均符合EULAR/ACR-19标准,确诊系统性红斑狼疮时未使用免疫抑制剂,随访时间最短为12个月。数据包括临床和实验室检查结果以及使用SLEDAI-2K的疾病活动度。采用接收者操作特征曲线(ROC)确定PIIV的最佳临界值,并评估其对疾病活动性和器官受累的预测潜力:共纳入 125 名患者(104 名女性),中位年龄为 16.0 岁(IQR 5.6),中位发病年龄为 10.9 岁(IQR 3.0),中位病程为 4.8 年(IQR 5.3)。确诊时最常累及的器官是血液(89.6%)、肌肉骨骼(68.8%)、粘膜(63.2%)和肾脏(58.4%)。然而,在 12 个月的随访中,最常受累的器官是肾脏(40.0%)、血液(39.2%)、肌肉骨骼(15.2%)和粘膜(10.4%)。诊断时的 PIIV 中位数为 139(IQR 229.6),诊断时和 12 个月后的 SLEDAI 中位数分别为 12(IQR 6.5)和 3.5(IQR 7.0)。研究发现,PIIV 的最佳临界值为 250,对疾病活动具有预测作用,敏感性为 45%,特异性为 86%。研究结果表明,PIIV 成功预测了患者群中的四个系统:我们的研究表明,PIIV可能是新诊断的系统性红斑狼疮患者器官受累和疾病活动性的合理预测指标,但还需要进一步的研究,特别是更大规模的研究来验证这些发现,尤其是关于器官受累的发现。
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Utility of pan-immune-inflammation value as a predictor of the prognosis of childhood lupus.

Background: Systemic lupus erythematosus (SLE) is a chronic inflammatory multisystemic disease. Monitoring disease activity thoughtout the disease course is important for effective management and assessment of disease outcome.

Objective: To assess whether the pan-immune inflammation value (PIIV) at diagnosis could predict organ involvement and disease activity in childhood SLE (cSLE) patients after 12 months of disease onst.

Methods: This is an observational retrospective multicenter study that comprised cSLE patients seen and followed at the participating centers between January 2010 and December 2022. All patients met the EULAR/ACR-19 criteria, were immunosuppressive drug-naïve at the time of SLE diagnosis and had a minimal follow-up period of 12 months. The data included clinical and laboratory findings and disease activity using the SLEDAI-2K. Receiver operating characteristic (ROC) curves were employed to determine the optimal cut-off value of PIIV and assess its predictive potential for disease activity, and organ involvement.

Results: A total of 125 patients (104 female) with a median age of 16.0 (IQR 5.6) years, a median age at disease onset of 10.9 (IQR 3.0) years, and a median disease duration of 4.8 (IQR 5.3) years were included. The most frequent involved organs at diagnosis were hematological (89.6%), musculoskeletal (68.8%), mucocutaneous (63.2%), and renal (58.4%). However, at a 12-month follow-up visit, the most frequent involved organs were renal (40.0%), hematological (39.2%), musculoskeletal (15.2%), and mucocutaneous (10.4%). The median PIIV at diagnosis was 139 (IQR 229.6), while the median SLEDAI was 12 (IQR 6.5) and 3.5 (IQR 7.0) at diagnosis and 12 months, respectively. An optimal PIIV cut-off of 250 was found to be a predicative for disease activity, with a sensitivity of 45% and a specificity of 86%. The study revealed that the PIIV successfully predicted four systems in our cohort of patients.

Conclusion: Our work suggests the PIIV might be a reasonable predictor for organ involvement and disease activity in newly diagnosed cSLE, though further research, particularly larger studies, is required to validate these findings, especially regarding organ involvement.

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来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
期刊最新文献
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