Dapeng Wang, Ning Li, Ruyuan Guo, Jing Pang, Li Zhang, Fuli Zhang, Junjie Zhang, Xiaotang Yang
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Using histopathological examination or postoperative pathological results as the diagnostic criteria, the sensitivity, specificity, and accuracy of endoscopy and iodine staining in diagnosing early cancer and precancerous lesions were evaluated.</p><p><strong>Results: </strong>Multiple lesions were identified by both methods, and pathological examination confirmed 86 lesions, including early squamous cell carcinoma and precancerous lesions, such as early esophageal cancer, high-grade esophageal intraepithelial neoplasia, and hypopharyngeal cancer. Endoscopy showed significantly higher accuracy, detection rate, sensitivity, and specificity in NBI mode than in white light mode (96.12%, 86.05%, 97.37%, 86.67% vs 86.05%, 76.74%, 86.84%, 80%, respectively; P < 0.05). NBI grading and iodine staining grading showed good consistency with pathological diagnosis, with a Kappa value of 0.684 and 0.622, respectively.</p><p><strong>Conclusions: </strong>NBI endoscopy allows for better observation of subtle structural changes on the surface of lesions compared to white light endoscopy. It provides high accuracy in detecting early laryngeal and hypopharyngeal cancer and precancerous lesions, determining biopsy sites, facilitating early diagnosis, and establishing safe surgical margins. NBI endoscopy offers a viable alternative for non-invasive screening and early diagnosis of laryngeal and hypopharyngeal cancer, showing great potential for clinical advancement.</p>","PeriodicalId":49954,"journal":{"name":"Journal of Voice","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinical Value of Narrow Band Imaging Endoscopy in the Early Diagnosis and Staging Assessment of Laryngeal and Hypopharyngeal Cancer.\",\"authors\":\"Dapeng Wang, Ning Li, Ruyuan Guo, Jing Pang, Li Zhang, Fuli Zhang, Junjie Zhang, Xiaotang Yang\",\"doi\":\"10.1016/j.jvoice.2024.07.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To explore the clinical value of narrow band imaging (NBI) endoscopy in the early diagnosis and staging assessment of laryngeal and hypopharyngeal cancer.</p><p><strong>Methods: </strong>A total of 78 patients with lesions in the hypopharynx or larynx were examined using endoscopy, observed under both white light and NBI modes, and graded using NBI. 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引用次数: 0
摘要
目的探讨窄带成像(NBI)内窥镜在喉癌和下咽癌早期诊断和分期评估中的临床价值:方法:共对78名下咽或喉部有病变的患者进行了内窥镜检查,在白光和窄带成像两种模式下进行观察,并使用窄带成像进行分级。使用鲁戈尔碘溶液对喉和下咽病变进行碘染色分级。以组织病理学检查或术后病理结果作为诊断标准,评估了内窥镜检查和碘染色诊断早期癌症和癌前病变的敏感性、特异性和准确性:结果:两种方法都能发现多个病灶,病理检查证实了86个病灶,包括早期鳞状细胞癌和癌前病变,如早期食管癌、高级别食管上皮内瘤变和下咽癌。在 NBI 模式下,内镜检查的准确性、检出率、灵敏度和特异性明显高于白光模式(分别为 96.12%、86.05%、97.37%、86.67% vs 86.05%、76.74%、86.84%、80%;P 结论:NBI 内镜检查能更好地观察食管癌和食管癌前病变,如早期食管癌、高级别食管上皮内瘤变和下咽癌:与白光内镜相比,NBI 内镜能更好地观察病变表面细微的结构变化。它在检测早期喉癌和下咽癌以及癌前病变、确定活检部位、促进早期诊断以及确定安全手术切缘方面具有很高的准确性。NBI 内窥镜为喉癌和下咽癌的无创筛查和早期诊断提供了一种可行的替代方法,显示出巨大的临床发展潜力。
Clinical Value of Narrow Band Imaging Endoscopy in the Early Diagnosis and Staging Assessment of Laryngeal and Hypopharyngeal Cancer.
Objective: To explore the clinical value of narrow band imaging (NBI) endoscopy in the early diagnosis and staging assessment of laryngeal and hypopharyngeal cancer.
Methods: A total of 78 patients with lesions in the hypopharynx or larynx were examined using endoscopy, observed under both white light and NBI modes, and graded using NBI. Using Lugol's iodine solution, laryngeal and hypopharyngeal lesions were graded using iodine staining. Using histopathological examination or postoperative pathological results as the diagnostic criteria, the sensitivity, specificity, and accuracy of endoscopy and iodine staining in diagnosing early cancer and precancerous lesions were evaluated.
Results: Multiple lesions were identified by both methods, and pathological examination confirmed 86 lesions, including early squamous cell carcinoma and precancerous lesions, such as early esophageal cancer, high-grade esophageal intraepithelial neoplasia, and hypopharyngeal cancer. Endoscopy showed significantly higher accuracy, detection rate, sensitivity, and specificity in NBI mode than in white light mode (96.12%, 86.05%, 97.37%, 86.67% vs 86.05%, 76.74%, 86.84%, 80%, respectively; P < 0.05). NBI grading and iodine staining grading showed good consistency with pathological diagnosis, with a Kappa value of 0.684 and 0.622, respectively.
Conclusions: NBI endoscopy allows for better observation of subtle structural changes on the surface of lesions compared to white light endoscopy. It provides high accuracy in detecting early laryngeal and hypopharyngeal cancer and precancerous lesions, determining biopsy sites, facilitating early diagnosis, and establishing safe surgical margins. NBI endoscopy offers a viable alternative for non-invasive screening and early diagnosis of laryngeal and hypopharyngeal cancer, showing great potential for clinical advancement.
期刊介绍:
The Journal of Voice is widely regarded as the world''s premiere journal for voice medicine and research. This peer-reviewed publication is listed in Index Medicus and is indexed by the Institute for Scientific Information. The journal contains articles written by experts throughout the world on all topics in voice sciences, voice medicine and surgery, and speech-language pathologists'' management of voice-related problems. The journal includes clinical articles, clinical research, and laboratory research. Members of the Foundation receive the journal as a benefit of membership.