游泳与褪黑素联合使用可防止脑缺血再灌注损伤大鼠的行为缺陷,这与调节 Mst1- MAPK -ERK 信号通路有关。

IF 2.5 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Archives of Physiology and Biochemistry Pub Date : 2024-08-17 DOI:10.1080/13813455.2024.2392186
Samah Mahmoud Abdelaal, Marwa Mohamed Abdel Rahman, Lamiaa Mohamed Mahmoud, Laila Ahmed Rashed, Tarek Ibrahim Abd El-Galil, Manal Moustafa Mahmoud
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引用次数: 0

摘要

背景:目的:我们旨在研究预处理游泳运动联合褪黑素对脑缺血再灌注(I/R)损伤的保护作用:将 60 只大鼠分为 6 组,I 组和 II 组为对照组。第 3、4、5、6 组进行双侧颈动脉结扎 30 分钟,然后再灌注。第 3 组不进行治疗,第 4 组和第 6 组在手术前三周进行游泳锻炼,每天 30 分钟,每周 5 天。第 5 组和第 6 组在手术前 30 分钟用褪黑素治疗,然后对第 4、5、6 组的所有大鼠进行再灌注。之后,第 5 组和第 6 组在再灌注后 30 分钟再注射第 2 次褪黑激素:结果:联合策略通过预防脑I/R诱导的炎症、氧化应激和细胞凋亡发挥了最大的神经保护作用,随后社会行为障碍得到改善,胶质细胞增殖能力增强:结论:联合策略的保护作用与巨噬细胞刺激 1/介原激活蛋白激酶/细胞外信号调节激酶(MST1/MAPK/ERK)通路的调节有关,这可能至少部分解释了其保护潜力。
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Combined swimming with melatonin protects against behavioural deficit in cerebral ischemia-reperfusion injury induced rats associated with modulation of Mst1- MAPK -ERK signalling pathway.

Background: The inconvenience of social and behavioural deficits after cerebral ischaemia reperfusion (I/R) injury is still not well documented.

Aim: We aimed to study the protective effect of preconditioning swimming exercise combined with melatonin against cerebral I/R induced injury.

Methodology: Sixty rats were allocated into 6 groups; groups I and II served as control. Groups 3,4,5,6 subjected to bilateral carotid ligation for 30 minutes (min.) followed by reperfusion. Group 3 left untreated while groups 4 and 6; underwent swimming exercise 30 min/day, five days a week for three weeks before the surgery. Groups 5 and 6 treated with melatonin 30 minutes before the operation, then, all rats in groups 4, 5,6 were subjected to I/R. After that, groups 5 and 6 treated with 2nd dose of melatonin 30 minutes after reperfusion.

Results: Combined strategy exhibited the most neuroprotective effect through prevention of cerebral I/R induced inflammation, oxidative stress and apoptosis with subsequent improvement in socio behaviour deficits and enhanced Glial cell proliferative capacity.

Conclusion: The protective contribution of combined strategy is associated with modulation in Macrophage-stimulating 1/mitogen-activated protein kinase/extracellular signal-regulated kinase (MST1/MAPK/ERK) pathway which may explain, at least in part, its protective potential.

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来源期刊
Archives of Physiology and Biochemistry
Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY
CiteScore
6.90
自引率
3.30%
发文量
21
期刊介绍: Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.
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