{"title":"药剂师指导的药物护理对心力衰竭患者健康相关和药物治疗相关生活质量的影响：随机对照试验。","authors":"Phantipa Sakthong , Warangkana Boonyanuwat","doi":"10.1016/j.sapharm.2024.08.003","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Data on the impact of pharmacist-led pharmaceutical care (PC) on pharmaceutical therapy-related and health-related quality of life (HRQoL) and their sensitivities to PC provision in patients with heart failure (HF) are scarce.</p></div><div><h3>Objectives</h3><p>This study aimed to assess the impact of pharmacist-led PC on HRQoL employing the Minnesota Living with Heart Failure Questionnaire (MLHFQ) and 5-level EuroQol 5 dimension (EQ-5D-5L) and on pharmaceutical therapy-related quality of life using the Patient-Reported Outcomes Measure of Pharmaceutical Therapy (PROMPT) in HF patients and compare sensitivities to the PC provision of these three tools.</p></div><div><h3>Methods</h3><p>A single-blinded randomized controlled trial was conducted at a tertiary public hospital in Thailand between November 2022 and May 2023. Overall, 250 patients were randomly divided into the usual care (UC) (N = 124) and PC (N = 126) groups. Mixed effects models were used to investigate the differences in the mean change scores of PROMPT, EQ-5D-5L, and MLHFQ between the UC and PC groups. The sensitivities to PC provision of the three measures were evaluated using standardized effect sizes (SESs).</p></div><div><h3>Results</h3><p>Significant differences were found in five of eight domains and the total score of the PROMPT between the PC and UC groups (all <em>p</em> < 0.05). However, no significant differences were found in the EQ-5D-5L and MLHFQ between the two groups (both <em>p</em> > 0.05). The SESs of the five domains and total score of PROMPT ranged from 0.29 to 1.65, considered small-to-large effect sizes, whereas the SESs of EQ-5D-5L and MLHFQ were −0.4 to 0, considered small effect sizes.</p></div><div><h3>Conclusions</h3><p>Pharmacist-led PC can positively affect pharmaceutical therapy-related quality of life using PROMPT in HF patients. Additionally, PROMPT is more sensitive to PC provision than EQ-5D-5L and MLHFQ.</p></div>","PeriodicalId":48126,"journal":{"name":"Research in Social & Administrative Pharmacy","volume":"20 11","pages":"Pages 1058-1063"},"PeriodicalIF":3.7000,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of pharmacist-led pharmaceutical care on health-related and pharmaceutical therapy-related quality of life in patients with heart failure: A randomized controlled trial\",\"authors\":\"Phantipa Sakthong , Warangkana Boonyanuwat\",\"doi\":\"10.1016/j.sapharm.2024.08.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Data on the impact of pharmacist-led pharmaceutical care (PC) on pharmaceutical therapy-related and health-related quality of life (HRQoL) and their sensitivities to PC provision in patients with heart failure (HF) are scarce.</p></div><div><h3>Objectives</h3><p>This study aimed to assess the impact of pharmacist-led PC on HRQoL employing the Minnesota Living with Heart Failure Questionnaire (MLHFQ) and 5-level EuroQol 5 dimension (EQ-5D-5L) and on pharmaceutical therapy-related quality of life using the Patient-Reported Outcomes Measure of Pharmaceutical Therapy (PROMPT) in HF patients and compare sensitivities to the PC provision of these three tools.</p></div><div><h3>Methods</h3><p>A single-blinded randomized controlled trial was conducted at a tertiary public hospital in Thailand between November 2022 and May 2023. Overall, 250 patients were randomly divided into the usual care (UC) (N = 124) and PC (N = 126) groups. Mixed effects models were used to investigate the differences in the mean change scores of PROMPT, EQ-5D-5L, and MLHFQ between the UC and PC groups. The sensitivities to PC provision of the three measures were evaluated using standardized effect sizes (SESs).</p></div><div><h3>Results</h3><p>Significant differences were found in five of eight domains and the total score of the PROMPT between the PC and UC groups (all <em>p</em> < 0.05). However, no significant differences were found in the EQ-5D-5L and MLHFQ between the two groups (both <em>p</em> > 0.05). The SESs of the five domains and total score of PROMPT ranged from 0.29 to 1.65, considered small-to-large effect sizes, whereas the SESs of EQ-5D-5L and MLHFQ were −0.4 to 0, considered small effect sizes.</p></div><div><h3>Conclusions</h3><p>Pharmacist-led PC can positively affect pharmaceutical therapy-related quality of life using PROMPT in HF patients. Additionally, PROMPT is more sensitive to PC provision than EQ-5D-5L and MLHFQ.</p></div>\",\"PeriodicalId\":48126,\"journal\":{\"name\":\"Research in Social & Administrative Pharmacy\",\"volume\":\"20 11\",\"pages\":\"Pages 1058-1063\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-08-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Research in Social & Administrative Pharmacy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1551741124002341\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Research in Social & Administrative Pharmacy","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1551741124002341","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
引用次数: 0
摘要
背景：有关药剂师主导的药物护理（PC）对心力衰竭（HF）患者药物治疗相关和健康相关生活质量（HRQoL）的影响及其对PC提供的敏感性的数据很少：本研究旨在评估药剂师指导的个人护理对明尼苏达心力衰竭患者生活调查问卷（MLHFQ）和欧洲心力衰竭五级标准（EQ-5D-5L）以及对心力衰竭患者药物治疗相关生活质量的影响，并比较这三种工具对个人护理的敏感性：2022 年 11 月至 2023 年 5 月期间，在泰国一家三级公立医院开展了一项单盲随机对照试验。共有 250 名患者被随机分为常规护理组（UC）（124 人）和 PC 组（126 人）。混合效应模型用于研究 UC 组和 PC 组之间 PROMPT、EQ-5D-5L 和 MLHFQ 平均变化分数的差异。使用标准化效应大小（SES）评估了三种测量方法对 PC 提供的敏感性：结果：PC 组和 UC 组在八个领域中的五个领域以及 PROMPT 总分上存在显著差异（均为 0.05）。五个领域和 PROMPT 总分的 SES 在 0.29 至 1.65 之间，属于小到大的效应量，而 EQ-5D-5L 和 MLHFQ 的 SES 在-0.4 至 0 之间，属于小的效应量：结论：药剂师指导的 PC 可以利用 PROMPT 对高血压患者与药物治疗相关的生活质量产生积极影响。此外，与 EQ-5D-5L 和 MLHFQ 相比，PROMPT 对提供 PC 更为敏感。
Impact of pharmacist-led pharmaceutical care on health-related and pharmaceutical therapy-related quality of life in patients with heart failure: A randomized controlled trial
Background
Data on the impact of pharmacist-led pharmaceutical care (PC) on pharmaceutical therapy-related and health-related quality of life (HRQoL) and their sensitivities to PC provision in patients with heart failure (HF) are scarce.
Objectives
This study aimed to assess the impact of pharmacist-led PC on HRQoL employing the Minnesota Living with Heart Failure Questionnaire (MLHFQ) and 5-level EuroQol 5 dimension (EQ-5D-5L) and on pharmaceutical therapy-related quality of life using the Patient-Reported Outcomes Measure of Pharmaceutical Therapy (PROMPT) in HF patients and compare sensitivities to the PC provision of these three tools.
Methods
A single-blinded randomized controlled trial was conducted at a tertiary public hospital in Thailand between November 2022 and May 2023. Overall, 250 patients were randomly divided into the usual care (UC) (N = 124) and PC (N = 126) groups. Mixed effects models were used to investigate the differences in the mean change scores of PROMPT, EQ-5D-5L, and MLHFQ between the UC and PC groups. The sensitivities to PC provision of the three measures were evaluated using standardized effect sizes (SESs).
Results
Significant differences were found in five of eight domains and the total score of the PROMPT between the PC and UC groups (all p < 0.05). However, no significant differences were found in the EQ-5D-5L and MLHFQ between the two groups (both p > 0.05). The SESs of the five domains and total score of PROMPT ranged from 0.29 to 1.65, considered small-to-large effect sizes, whereas the SESs of EQ-5D-5L and MLHFQ were −0.4 to 0, considered small effect sizes.
Conclusions
Pharmacist-led PC can positively affect pharmaceutical therapy-related quality of life using PROMPT in HF patients. Additionally, PROMPT is more sensitive to PC provision than EQ-5D-5L and MLHFQ.
期刊介绍：
Research in Social and Administrative Pharmacy (RSAP) is a quarterly publication featuring original scientific reports and comprehensive review articles in the social and administrative pharmaceutical sciences. Topics of interest include outcomes evaluation of products, programs, or services; pharmacoepidemiology; medication adherence; direct-to-consumer advertising of prescription medications; disease state management; health systems reform; drug marketing; medication distribution systems such as e-prescribing; web-based pharmaceutical/medical services; drug commerce and re-importation; and health professions workforce issues.
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