Yuan-Hong Yang , Qun-Zheng Zhang , Si-Chang Wang , Yu-Qing Shan , Cong-Yu Ke
{"title":"螺旋环状环戊并吡啶的高效合成路线","authors":"Yuan-Hong Yang , Qun-Zheng Zhang , Si-Chang Wang , Yu-Qing Shan , Cong-Yu Ke","doi":"10.1016/j.tetlet.2024.155250","DOIUrl":null,"url":null,"abstract":"<div><p>Pyridine spirocycles play an important role in drug design and development. In this paper, a novel spirocyclic cyclopentapyridine compound was synthesized. Based on retrosynthesis analysis, commercially available 2-chloro-6-methoxypyridine was used as the starting material for the synthesis of the target molecule, accomplished through an eight-step reaction process. Particular emphasis was placed on the two most challenging steps: selective <em>Negishi coupling</em> and carbonyl reduction.</p></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"149 ","pages":"Article 155250"},"PeriodicalIF":1.5000,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"An efficient route for synthesis of spirocyclic cyclopentapyridines\",\"authors\":\"Yuan-Hong Yang , Qun-Zheng Zhang , Si-Chang Wang , Yu-Qing Shan , Cong-Yu Ke\",\"doi\":\"10.1016/j.tetlet.2024.155250\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Pyridine spirocycles play an important role in drug design and development. In this paper, a novel spirocyclic cyclopentapyridine compound was synthesized. Based on retrosynthesis analysis, commercially available 2-chloro-6-methoxypyridine was used as the starting material for the synthesis of the target molecule, accomplished through an eight-step reaction process. Particular emphasis was placed on the two most challenging steps: selective <em>Negishi coupling</em> and carbonyl reduction.</p></div>\",\"PeriodicalId\":438,\"journal\":{\"name\":\"Tetrahedron Letters\",\"volume\":\"149 \",\"pages\":\"Article 155250\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2024-08-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tetrahedron Letters\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0040403924003459\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron Letters","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040403924003459","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
An efficient route for synthesis of spirocyclic cyclopentapyridines
Pyridine spirocycles play an important role in drug design and development. In this paper, a novel spirocyclic cyclopentapyridine compound was synthesized. Based on retrosynthesis analysis, commercially available 2-chloro-6-methoxypyridine was used as the starting material for the synthesis of the target molecule, accomplished through an eight-step reaction process. Particular emphasis was placed on the two most challenging steps: selective Negishi coupling and carbonyl reduction.
期刊介绍：
Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
